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CAS RN: 99300-78-4 | Product Number: V0110
Venlafaxine Hydrochloride
Purity: >98.0%(T)(HPLC)
Synonyms:
- 1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol Hydrochloride
Product Documents:
Size | Unit Price | Same Day | 2-3 Business Days | Quantity |
---|---|---|---|---|
1G |
S$43.50
|
2 | 9 |
|
5G |
S$136.50
|
18 | 1 |
|
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* The storage conditions are subject to change without notice.
Product Number | V0110 |
Purity / Analysis Method | >98.0%(T)(HPLC) |
Molecular Formula / Molecular Weight | C__1__7H__2__7NO__2·HCl = 313.87 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
Condition to Avoid | Light Sensitive |
Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
CAS RN | 99300-78-4 |
Related CAS RN | 93413-69-5 |
Reaxys Registry Number | 4240401 |
PubChem Substance ID | 125307750 |
SDBS (AIST Spectral DB) | 52922 |
Merck Index (14) | 9946 |
MDL Number | MFCD03658865 |
Specifications
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(Nonaqueous Titration) | min. 98.0 % |
Properties (reference)
Melting Point | 217 °C |
Solubility (soluble in) | Methanol |
GHS
Pictogram | |
Signal Word | Danger |
Hazard Statements | H302 : Harmful if swallowed. H370 : Causes damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. |
Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
Related Laws:
RTECS# | QV8872760 |
Transport Information:
H.S.code* | 2922.50-000 |
Application
Venlafaxine Hydrochloride: A Serotonin/Norepinephrine Reuptake Inhibitor (SNRI)
Venlafaxine hydrochloride belongs to a serotonin [S0370] /norepinephrine [A0906] reuptake inhibitors (SNRIs). Studies have shown that venlafaxine and its active metabolite, O-desmethylvenlafaxine (ODV) [D5598], are potent inhibitors of neuronal serotonin and norepinephrine reuptake and weak inhibitors of dopamine [A0305] reuptake. Venlafaxine and ODV have no significant affinity for muscarinic cholinergic, H1-histaminergic, or α1-adrenergic receptors in vitro. For your reference, duloxetine hydrochloride [D4223] and milnacipran hydrochloride [M2133] also belong to SNRIs. (The product is for research purpose only.)
References
- Biochemical, neurophysiological, and behavioral effects of Wy-45,233 and other identified metabolites of the antidepressant venlafaxine
- Venlafaxine oxidation in vitro is catalyzed by CYP2D6
- Venlafaxine: a review of its pharmacology and therapeutic potential in depression (a review)
- Comparative Affinity of Duloxetine and Venlafaxine for Serotonin and Norepinephrine Transporters in vitro and in vivo, Human Serotonin Receptor Subtypes, and Other Neuronal Receptors
- Use of vancomycin silica stationary phase in packed capillary electrochromatography. II. Enantiomer separation of venlafaxine and O-desmethylvenlafaxine in human plasma
- Development and validation of stability indicating method for the quantitative determination of venlafaxine hydrochloride in extended release formulation using high performance liquid chromatography
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