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CAS RN: 404950-80-7 | Product Number: P3137

Panobinostat


Purity: >93.0%(HPLC)
Synonyms:
  • (2E)-N-Hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide
  • (E)-N-Hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]acrylamide
  • LBH 589
Product Documents:
10MG
S$82.50
14   20   It can be shipped in about 2 weeks after ordering

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* The storage conditions are subject to change without notice.


Product Number P3137
Purity / Analysis Method >93.0%(HPLC)
Molecular Formula / Molecular Weight C__2__1H__2__3N__3O__2 = 349.43 
Physical State (20 deg.C) Solid
Storage Temperature Refrigerated (0-10°C)
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive,Heat Sensitive
CAS RN 404950-80-7
Reaxys Registry Number 12257756
MDL Number

MFCD09833242

Specifications
Appearance White to Light yellow to Light orange powder to crystal
Purity(HPLC) min. 93.0 area%
NMR confirm to structure
Properties (reference)
Melting Point 115 °C
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
H361 : Suspected of damaging fertility or the unborn child.
H370 : Causes damage to organs.
H372 : Causes damage to organs through prolonged or repeated exposure.
H341 : Suspected of causing genetic defects.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P260 : Do not breathe dust.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
Transport Information:
UN Number UN2811
Class 6.1
Packing Group III
H.S.code* 2933.99-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
Panobinostat (LBH589): A Histone Deacetylase (HDAC) Inhibitor

Histone deacetylases (HDACs) catalyze the removal of acetyl groups from the lysine residues of histones and some non-histone proteins and play important roles in maintaining chromatin structure and regulating gene expression, including tumor suppressor genes, and thus represent valid targets in the search for cancer therapeutics. Panobinostat (LBH589) has been reported to inhibit the enzymatic activity of HDACs implicated in cancer and has demonstrated potent anti-tumor activity. (The product is for research purpose only.)

References


Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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