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CAS RN: 107133-36-8 | Product Number: P2968
Perindopril Erbumine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- Perindopril tert-Butylamine Salt
- (2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-Ethoxy-1-oxo-2-pentanyl]amino]propanoyl]octahydro-1H-indole-2-carboxylic Acid 2-Methyl-2-propanamine
- (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic Acid tert-Butylamine Salt
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time | Quantity |
Shipping Information
|
|---|---|---|---|---|---|---|
| 200MG |
S$118.50
|
10 | 0 | Contact Us |
|
|
| 1G |
S$406.50
|
28 | 0 | Contact Us |
|
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* The storage conditions are subject to change without notice.
| Product Number | P2968 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__3__2N__2O__5·C__4H__1__1N = 441.61 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image), 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 107133-36-8 |
| Reaxys Registry Number | 4285797 |
| MDL Number | MFCD02313824 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation | -65.0 to -70.0 deg(C=1, ethanol) |
| NMR | confirm to structure |
Properties (reference)
| Solubility in water | Soluble |
| Solubility (soluble in) | Ethanol |
GHS
Related Laws:
| RTECS# | NL5999600 |
Transport Information:
| H.S.code* | 2933.99-000 |
Application
Perindopril Erbumine: A Long Acting Angiotensin Converting Enzyme (ACE) Inhibitor
Perindopril erbumine (S-9490-3) is an oral prodrug ester of perindoprilat, an inhibitor of angiotensin converting enzyme (ACE), which effectively lowers blood pressure. ACE catalyzes conversion of the inactive decapeptide, angiotensin I, to the vasoconstrictor, angiotensin II. Angiotensin II is a potent peripheral vasoconstrictor, which stimulates aldosterone secretion by the adrenal cortex, and provides on renin secretion. ACE inhibitors, such as perindopril occupy the active center of the enzyme so that cleavage of angiotensin I is inhibited competitively. (The product is for research purpose only.)
References
- Comparison of the Actions of the Angiotensin-Converting Enzyme Inhibitors Enalapril and S-9490-3 in Sodium-Deplete and Sodium-Replete Spontaneously Hypertensive Rats
- Perindopril. An updated review of its use in hypertension
- Desirability-based optimization and its sensitivity analysis for the perindopril and its impurities analysis in a microemulsion LC system
- Analytical Techniques for the Estimation of Perindopril Erbumine: A Review
Product Documents (Note: Some products will not have analytical charts available.)
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