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CAS RN: 826-39-1 | Product Number: M3503
Mecamylamine Hydrochloride
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Purity: >98.0%(T)
Synonyms:
- Inversine
- N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine Hydrochloride
- N,2,3,3-Tetramethyl-2-norbornanamine Hydrochloride
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Quantity |
|---|---|---|---|---|
| 50MG |
S$300.00
|
≥40 | Contact Us |
|
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to order TCI products.
* The storage conditions are subject to change without notice.
| Product Number | M3503 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__1__1H__2__1N·HCl = 203.75 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic |
| CAS RN | 826-39-1 |
| Reaxys Registry Number | 7097642 |
| MDL Number | MFCD00151462 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(Volumetric Analysis) | min. 98.0 % |
| Purity(Precipitation Titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | RB6900000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2921.30-000 |
Application
Mecamylamine Hydrochloride: A Nicotinic Acetylcholine Receptors (nAChRs) Antagonist
Mecamylamine hydrochloride is a non-selective, non-competitive antagonist of the nicotinic acetylcholine receptors (nAChRs). It was developed as an antihypertensive agent in the 1950s, but is rarely used today for hypertension because of its widespread ganglionic side effects, and is more often now as a neuro research tool. Mecamylamine easily traverses the blood-brain barrier to reach the central nervous system (CNS), where it acts as a nicotinic acetylcholine receptor antagonist.1-5) This effect is thought to be due to antagonist effects at the α4β2 nicotinic receptors in the brain.4) Recently, it is expected to be used as an agent in treating CNS disorders, including nicotine and alcohol addiction in clinical.5) (The product is for research purpose only.)
References
- 1) Analysis of mecamylamine stereoisomers on human nicotinic receptor subtypes
- 2) Blockade of nicotine self-administration with nicotinic antagonists in rats
- 3) Nicotinic acetylcholine receptors as targets for antidepressants (a review)
- 4) TC-5214 (S-(+)-mecamylamine): a neuronal nicotinic receptor modulator with antidepressant activity
- 5) Potential therapeutic uses of mecamylamine and its stereoisomers
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Specifications
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