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CAS RN: 1485-00-3 | Product Number: M3390
MNS
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Purity: >98.0%(GC)
Synonyms:
- 3,4-Methylenedioxy-β-nitrostyrene
- 5-(2-Nitrovinyl)-1,3-benzodioxole
- 5-(2-nitrovinyl)benzo[d][1,3]dioxole
- MDBN
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time | Quantity |
Shipping Information
|
|---|---|---|---|---|---|---|
| 100MG |
S$97.50
|
11 | 0 | Contact Us |
|
|
| 500MG |
S$342.00
|
13 | 0 | Contact Us |
|
* Please contact our distributors or
TCI
to order TCI products.
* The storage conditions are subject to change without notice.
| Product Number | M3390 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__9H__7NO__4 = 193.16 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Heat Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image), 500MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 1485-00-3 |
| Reaxys Registry Number | 15499 |
| PubChem Substance ID | 468592438 |
| MDL Number | MFCD00014575 |
Specifications
| Appearance | Light yellow to Yellow to Green powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 159.0 to 163.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 161 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | WL5270000 |
Transport Information:
| H.S.code* | 2932.99-000 |
Application
MNS: A Potent Antiplatelet Agent with Tyrosine Kinase Inhibitory Activity, and a NLRP3 Inflammasome Inhibitor
MNS, the β-nitrostyrene derivative, is a potent antiplatelet agent with tyrosine kinase inhibitory activity.1,2) It has recently been reported that NLR family pyrin domain-containing protein 3 (NLRP3), a pattern recognition receptor, forms a complex called NLRP3 inflammasome in response to irritating metabolites and pathogens, and induces the production of pro-inflammatory cytokines, Interleukin (IL)-1β and IL-18. MNS has also attracted attention as a NLRP3 inflammasome inhibitor which shows anti-inflammatory activity.3,4) (The product is for research purpose only.)
References
- 1) Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-β-nitrostyrene, a novel tyrosine kinase inhibitor
- 2) Synthesis and pharmacological evaluation of novel β-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity
- 3) 3,4-Methylenedioxy-β-nitrostyrene Inhibits NLRP3 Inflammasome Activation by Blocking Assembly of the Inflammasome
- 4) 3,4-Methylenedioxy-β-Nitrostyrene Ameliorates Experimental Burn Wound Progression by Inhibiting the NLRP3 Inflammasome Activation
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