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CAS RN: 307538-42-7 | Product Number: M3106
SMER 28
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Purity: >98.0%(HPLC)
Synonyms:
- N-Allyl-6-bromoquinazolin-4-amine
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time | Quantity |
Shipping Information
|
|---|---|---|---|---|---|---|
| 25MG |
S$156.00
|
9 | 3 | Contact Us |
|
|
| 100MG |
S$465.00
|
12 | 1 | Contact Us |
|
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* The storage conditions are subject to change without notice.
| Product Number | M3106 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__1H__1__0BrN__3 = 264.13 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 307538-42-7 |
| Reaxys Registry Number | 11300505 |
| PubChem Substance ID | 354335754 |
| MDL Number | MFCD02166825 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 15.00 to 16.70 % |
| Melting point | 167.0 to 171.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 169 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| H.S.code* | 2933.59-000 |
Application
SMER28: A Small-Molecular Enhancer of Autophagy
SMER28 has been reported as a small-molecular enhancer of autophagy, inducing autophagy independently of the mTOR pathway. SMER28 has also reported to decrease the levels of Amyloid beta (Aβ) peptide. Therefore, SMER28 may have therapeutic potential for the treatment of Alzheimer's disease and other protein-pathologies.
References
- Small molecules enhance autophagy and reduce toxicity in Huntington's disease models
- A small-molecule enhancer of autophagy decreases levels of Aβ and APP-CTF via Atg5-dependent autophagy pathway
- Autophagy Modulates Articular Cartilage Vesicle Formation in Primary Articular Chondrocytes
PubMed Literature
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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