text.skipToContent text.skipToNavigation

Published TCIMAIL newest issue No.198 | Product Document Searching Made Easy by 2D Code! | TCI Materials Science News March 2025 | [TCIPracticalExample] Synthesis of a Silyl Enol Ether Using... | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)

Singapore

English

My Account

Quotes

Saved Carts

Account Details

Sign Out
Sign In
- Sign in
- Register
S$0.00

- Sign in
- Register

Maximum quantity allowed is 999

Please select the quantity

CAS RN: 133745-75-2 | Product Number: F0335

N-Fluorobenzenesulfonimide [Fluorinating Reagent]

Purity: >98.0%(T)(HPLC)

Synonyms:

N-Fluorobis(phenylsulfonyl)amine
NFSI
NFBS

Product Documents:

Size	Unit Price	Same Day	2-3 Business Days	Other Lead Time	Quantity	Shipping Information
5G	S$46.50	≥40	≥100	It can be shipped in about 2 weeks after ordering		Shipping Simulation
25G	S$163.50	≥60	≥80	It can be shipped in about 2 weeks after ordering		Shipping Simulation

* Please contact our distributors or TCI to order TCI products.
* The storage conditions are subject to change without notice.

Added to Your Shopping Cart

General Information plus

Product Number	F0335
Purity / Analysis Method	>98.0%(T)(HPLC)
Molecular Formula / Molecular Weight	C₁₂H₁₀FNO₄S₂ = 315.33
Physical State (20 deg.C)	Solid
Storage Temperature	Room Temperature (Recommended in a cool and dark place, <15°C)
CAS RN	133745-75-2
Reaxys Registry Number	5348902
PubChem Substance ID	87570107
SDBS (AIST Spectral DB)	19601
MDL Number	MFCD00144885

Specifications & Properties plus

Safety & Regulations plus

GHS

Pictogram
Signal Word	Warning
Hazard Statements	H315 : Causes skin irritation. H319 : Causes serious eye irritation. H341 : Suspected of causing genetic defects.
Precautionary Statements	P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P405 : Store locked up.

Related Laws:

Transport Information:

H.S.code*

2935.90-000

*This code is applied to the products when TCI exports from Japan and not for import in your country.

Applications & Literature plus

Application

TCI Practical Example: One-Pot Palladium-Catalyzed Fluorosulfonylation of an Aryl Bromide Using DABSO and NFSI

パラジウム触媒によるDABSOとNFSIを用いたアリールブロミドのワンポットフッ化スルホニル化

Used Chemicals

Procedure: To a solution of 4-bromobiphenyl (1.17 g, 5.00 mmol), DABSO (721 mg, 3.00 mmol), and PdCl₂(Amphos)₂ (177 mg, 0.25 mmol) in anhydrous isopropyl alcohol (20 mL) was added triethylamine (2.1 mL, 15 mmol) at room temperature and the mixture was stirred at 75 °C for 23 hours. The suspension was cooled at room temperature and NFSI (2.36 g, 7.5 mmol) was added and the reaction mixture stirred for 3 hours until completion. The solvent was removed under reduced pressure. The residue was diluted with ethyl acetate (20 mL) and filtrated through celite pad. The filtrate was washed with saturated aqueous Na₂S₂O₃ solution (20 mL) and brine (20 mL), dried over sodium sulfate and filtered. The solvent was removed under reduced pressure and the residue was purified by medium pressure preparative chromatography (ethyl acetate:hexane = 2:98 - 5:95 on silica gel) to give compound 1 as a white solid (928 mg, 79%).

Experimenter’s Comments: The reaction mixture was monitored by TLC (ethyl acetate:hexane = 1:9, Rf = 0.57) and UPLC-MS.

Analytical Data

Compound 1

¹H NMR (400 MHz, CDCl₃); δ 8.12–8.04 (m, 2H), 7.86–7.80 (m, 2H), 7.67–7.58 (m, 2H), 7.44-7.55 (m, 3H).

Lead Reference

One-pot palladium-catalyzed synthesis of sulfonyl fluorides from aryl bromides

A. T. Davies, J. M. Curto, S. W. Bagley, M. C. Willis, Chem. Sci. 2017, 8, 1233.

Application

An Enantioselective Fluorination of α-Branched Aldehydes Using Newly Developed Chiral Amine Catalyst

E1267, F0335

Typical Procedure (synthesis of 2-fluoro alcohol; Ar=Ph, R¹=CH₃):
To a solution of the chiral amine catalyst [E1267] (20 mg, 0.026 mmol, 10 mol%) in toluene (0.54 mL) is added 3,5-dinitrobenzoic acid (5.5 mg, 0.026 mmol, 10 mol%), 2-phenylpropionaldehyde (52 mg, 0.39 mmol, 1.5 eq.), and N-fluorobenzenesulfonimide (NFSI) (0.26 mmol, 82 mg, 1 eq.) at 0 °C. The reaction mixture is stirred at 0 °C for 48 h, then poured into CH₃OH/CH₂Cl₂ (1:4, 1.3 mL) at 0 °C. To this solution, NaBH₄ (1.6 mmol, 6 eq.) is added, and the mixture is stirred at room temperature for 1 h. The reaction is quenched with saturated aq.NH₄Cl, and the mixture is extracted with Et₂O. The organic layer is dried over Na₂SO₄, and concentrated. The residue is purified by silica gel chromatography (eluent: hexane/ethyl acetate = 3/1) to give (S)-2-fluoro-2-phenylpropan-1-ol (34.5 mg, 86% yield based on NFSI, 95% ee) as a white solid.

References

K. Shibatomi, K. Kitahara, T. Okimi, Y. Abe, S. Iwasa, Chem. Sci. 2016, 7, 1388.

Application

Copper-catalyzed Direct Amidation of Heterocycles with N-Fluorobenzenesulfonimide

F0335

Typical Procedure:
In a dry 25 mL round-bottom flask, thiophene (0.5 mmol, 1 eq.), NFSI (0.6 mmol, 1.2 eq.) and CuI (5 mol%) are dissolved in DCE (3 mL), the resulting mixture is put into a preheated oil bath (60 °C) for 8 h. The solution is then cooled to room temperature, evaporated under reduced pressure, diluted with ethyl acetate, washed with a saturated aqueous solution of NaCl, dried over Na₂SO₄, filtered and evaporated under reduced pressure. The crude product is purified by silica gel column chromatography to afford the corresponding product (166.7 mg, Y. 88 %).

References

S. Wang, Z. Ni, X. Huang, J. Wang, Y. Pan, Org. Lett. 2014, 16, 5648.

Application

Synthesis of Stereoseletive 1-Indanone Derivatives

Reference

J. Nie, H.-W. Zhu, H.-F. Cui, M.-Q. Hua, J.-A. Ma, Org. Lett. 2007, 9, 3053.

PubMed Literature

Articles/Brochures

TCIMAIL

[Research Articles] An Enantioselective Fluorination of α-Branched Aldehydes Using Newly Developed Chiral Amine Catalyst
[Research Articles] Copper-catalyzed Direct Amidation of Heterocycles with N-Fluorobenzenesulfonimide
[TCI Practical Example] One-Pot Palladium-Catalyzed Fluorosulfonylation of an Aryl Bromide Using DABSO and NFSI

Product Documents (Note: Some products will not have analytical charts available.)

Safety Data Sheet (SDS)

Language

Please select Language.

The requested SDS is not available.

Please Contact Us for more information.

Specifications

C of A & Other Certificates

Type

Lot Number

Please enter Lot Number Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.

Sample C of A

This is a sample C of A and may not represent a recently manufactured lot of the product.

A sample C of A for this product is not available at this time.

Analytical Charts

Type

Lot Number

Please enter Lot Number Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.

The requested analytical chart is not available. Sorry for the inconvenience.

Product Categories

Chemistry

Synthetic Reagents

Fluorination Reagents [Synthetic Reagents]

Fluorination [Synthetic Reagents]

Electrophilic Fluorinating Agents

Chemistry

Synthetic Reagents

Fluorination Reagents [Synthetic Reagents]

Fluorination [Synthetic Reagents]

Electrophilic Fluorinating Agents

Appearance	White to Light yellow powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(Iodometric Titration)	min. 98.0 %
Melting point	115.0 to 119.0 °C

Americas

Europe

Asia Pacific

Africa & Middle East

CAS RN: 133745-75-2 | Product Number: F0335

N-Fluorobenzenesulfonimide [Fluorinating Reagent]

Used Chemicals

Procedure

Experimenter’s Comments

Analytical Data

Lead Reference

References

References

Reference

Articles/Brochures

Safety Data Sheet (SDS)

Specifications

C of A & Other Certificates

Sample C of A

Analytical Charts

Other Documents

Product Categories

Chemistry

Chemistry

How To Order

About TCI

Select Country or Region & Language

Americas

Europe

Asia Pacific

Africa & Middle East

CAS RN: 133745-75-2 | Product Number: F0335

N-Fluorobenzenesulfonimide [Fluorinating Reagent]

Used Chemicals

Procedure

Experimenter’s Comments

Analytical Data

Lead Reference

References

References

Reference

Articles/Brochures

Safety Data Sheet (SDS)

Specifications

C of A & Other Certificates

Sample C of A

Analytical Charts

Other Documents

Product Categories

Chemistry

Chemistry