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CAS RN: 4143-62-8 | Product Number: D4794
3',4'-Dimethoxyflavone
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Purity: >98.0%(GC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 200MG |
€34.00
|
1 | 2 |
|
|
| 1G |
€119.00
|
1 | 19 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | D4794 |
Purity / Analysis Method 
|
>98.0%(GC) |
| Molecular Formula / Molecular Weight | C__1__7H__1__4O__4 = 282.30 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 4143-62-8 |
| Reaxys Registry Number | 236749 |
| PubChem Substance ID | 354333484 |
| MDL Number | MFCD00143009 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 151.0 to 155.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 153 °C |
| Maximum Absorption Wavelength | 334 nm (MeOH) |
GHS
Related Laws:
| RTECS# | DJ3012950 |
Transport Information:
| HS Number | 2932990090 |
Application
3',4'-Dimethoxyflavone: An Inhibitor of Poly (ADP-Ribose) Polymerase (PARP) Enzymes
Genomic instability is a hallmark of cancer and is often the result of altered DNA repair capabilities in tumor cells. Poly (ADP-ribose) polymerases (PARPs) are enzymes responsible for DNA damage detection and repair factor recruitment. PARP inhibitors are able to interact with the binding site for the PARP cofactor NAD+ and trap PARP on DNA, and induce cell death through replication stress-induced mitotic catastrophe. It has been reported that 3',4'-dimethoxyflavone is a PARP inhibitor and has neuroprotective effects. (The product is for research use only.)
Reference
- Identification through high-throughput screening of 4'-methoxyflavone and 3',4'-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos
PubMed Literature
Product Documents (Note: Some products will not have analytical charts available.)
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