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CAS RN: 38821-49-7 | Product Number: C2450
Carbidopa Monohydrate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropionic Acid Monohydrate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
€28.00
|
1 | 3 |
|
| 1G |
€178.00
|
1 | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C2450 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__4N__2O__4·H__2O = 244.25 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 38821-49-7 |
| Related CAS RN | 28860-95-9 |
| Reaxys Registry Number | 4189448 |
| PubChem Substance ID | 125307806 |
| SDBS (AIST Spectral DB) | 52879 |
| MDL Number | MFCD00889211 |
Specifications
| Appearance | White to Light yellow powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 %(calcd.on dried substance) |
| Specific rotation [a]20/D | -21.0 ～ -23.5 deg(C=1, AlCl3 sol.) |
| Drying loss | 5.9 to 8.8 % |
Properties (reference)
| Specific Rotation | -22° (C=1,AlCl3 sol.) |
GHS
Related Laws:
| RTECS# | MW5300000 |
Transport Information:
| HS Number | 2928009090 |
Application
Carbidopa: A Competitive Inhibitor of Aromatic L-Amino Acid Decarboxylase
Carbidopa is a competitive inhibitor of aromatic L-amino acid decarboxylase. Carbidopa is often used with L-DOPA [D0600] for the treatment of Parkinson's disease. L-DOPA, the metabolic precursor of dopamine [A0305], does cross the blood-brain barrier, and presumably is converted to dopamine in the brain. However, when L-DOPA is administered orally, it is rapidly decarboxylated to dopamine in extracerebral tissues. Administration of dopamine alone is ineffective in the treatment of Parkinson's disease apparently because dopamine does not cross the blood-brain barrier. Carbidopa inhibits decarboxylation of L-DOPA. Since its decarboxylase inhibiting activity is limited to extracerebral tissues, administration of carbidopa with levodopa makes more L-DOPA available for transport to the brain. Carbidopa does not cross the blood-brain barrier and does not affect the metabolism of L-DOPA within the central nervous system. (The product is for research purpose only.)
References
- L-Dopa Therapy Combined with Peripheral Decarboxylase Inhibitor (MK-486) in Parkinsonism
- Metabolism of Carbidopa [L-(-)-α-Hydrazino-3,4-dihydroxy-α-methylhydrocinnamic Acid Monohydrate], an Aromatic Amino Acid Decarboxylase Inhibitor, in the Rat, Dog, Rhesus Monkey, and Man
- Levodopa and decarboxylase inhibitors: a review of their clinical pharmacology and use in the treatment of Parkinsonism
- Treatment of Parkinson's disease in the advanced stage (a review)
- Automated determination of levodopa and carbidopa in plasma by high-performance liquid chromatography-electrochemical detection using an online flow injection analysis sample pretreatment unit
- Quantitative analysis of levodopa, carbidopa and methyldopa in human plasma samples using HPLC-DAD combined with second-order calibration based on alternating trilinear decomposition algorithm
PubMed Literature
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