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CAS RN: 128302-78-3 | Product Number: B5370
(tert-Butyldimethylsilyloxy)malononitrile
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Purity: >93.0%(GC)
Synonyms:
- (tert-Butyldimethylsilyloxy)propanedinitrile
- MAC-TBS Reagent
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 200MG |
€119.00
|
Contact Us | 16 |
|
| 1G |
€380.00
|
1 | 26 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | B5370 |
| Purity / Analysis Method | >93.0%(GC) |
| Molecular Formula / Molecular Weight | C__9H__1__6N__2OSi = 196.33 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 128302-78-3 |
| Reaxys Registry Number | 3602433 |
| PubChem Substance ID | 354334748 |
| MDL Number | MFCD27942977 |
Specifications
| Appearance | White to Yellow to Green clear liquid |
| Purity(GC) | min. 93.0 % |
| NMR | confirm to structure |
Properties (reference)
| Flash point | 87 °C |
| Refractive Index | 1.43 |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P261 : Avoid breathing mist or vapours. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. |
Related Laws:
Transport Information:
| UN Number | UN3276 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2931900090 |
Application
MAC-TBS Reagent Usable for Three Component Coupling Reactions
Synthesis of an α-siloxy-Weinreb amide3): To a solution of aldehyde (1.0 mmol), DMHA·HCl (117 mg, 1.2 mmol), and 1 (236 mg, 1.2 mmol) in acetonitrile (3 mL) is added DMAP (244 mg, 2.0 mmol) at room temperature, and the resulting mixture is stirred for 2 h, and then concentrated in vacuo. The residue is purified by silica gel column chromatography to afford the corresponding product.
References
- 1)Development of a new acyl anion equivalent for the preparation of masked activated esters, and their use to prepare a dipeptide
- 2)A New One-Pot Method for the Synthesis of α-Siloxyamides from Aldehydes or Ketones and Its Application to the Synthesis of (－)-Bestatin
- 3)Direct One-Pot Synthesis of α-Siloxy-Weinreb Amides from Aldehydes
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