Maximum quantity allowed is 999
c-Jun N-Terminal Kinase (JNK) Inhibitor
IQ-1 (1) is an inhibitor of LPS-induced NF-κB/AP-1 activation with IC50 of 2.3±0.41 μM,1) and binds to the c-Jun N-terminal kinase (JNK) family with the affinities as shown in Table 1. According to molecular docking analysis, the amine moiety in the Asn152 side-chain of JNK3 forms hydrogen bonds with both nitrogen and oxygen atoms in the oxime moiety of 1. 1 also inhibits pro-inflammatory cytokines* and nitric oxide production by human and murine monocyte/macrophages. In addition, the compound allows for the Wnt/β-catenin-driven long-term expansion of mouse ESCs and prevents spontaneous differentiation.2)
*In reference 1, the authors show that interleukin (IL)-1α, IL-1β, IL-6, IL-10, tumor necrosis factor (TNF)-α, interferon-γ, and granulocyte-macrophage colony-stimulating factor are inhibited by 1.
Table 1. Binding affinity of 1 to each kinase1)
References
- 1) Identification and Characterization of a Novel Class of c-Jun N-terminal Kinase Inhibitors
- 2) Wnt/β-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency
The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.