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Glycoamino Acid
No.120(June 2004)
Glycoamino Acid 1 consists of glucose and asparagine, and Inazu and his coworkers has reported an excellent synthetic method for this compound in recent years.1) 1 can be utilized for the syntheses of N-(asparagine-linked) glycoprotein and glycopeptides. For example, 1 reacts with peptides 2 supported by silica gel to produce glycopeptides 3. In addition, the resulting 3 can be reacted with N-acetylglucosamine or oligosaccharides by using glycosyltransferase making the sugar chain elongation possible.2)
References
- 1)Preparation of asparagine-containing glycopeptides
- K. Haneda, T. Inazu, K. Yamamoto, H. Kumagai, Y. Nakahara, A. Kobata, Carbohydr. Res. 1996, 292, 61.
- T. Inazu, M. Mizuno, Chem. Abs. 129, 289269.
- 2)Synthesis of glycopeptides and oligosaccharides
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