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CAS RN: 52-24-4 | Product Number: T4184
Thiotepa
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Purity: >95.0%(HPLC)
Synonyms:
- Thio-TEPA
- Tri(aziridin-1-yl)phosphine Sulfide
- 1-[Bis(1-aziridinyl)phosphorothioyl]aziridine
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
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|---|---|---|---|---|---|
| 250MG |
$346.00
|
17 | 0 | Contact Us |
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| Product Number | T4184 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__6H__1__2N__3PS = 189.22 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 250MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 52-24-4 |
| Reaxys Registry Number | 145978 |
| MDL Number | MFCD00145452 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Melting point | 52.0 to 56.0 °C |
| Water | max. 2.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 54 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. H360 : May damage fertility or the unborn child. H371 : May cause damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H340 : May cause genetic defects. H350 : May cause cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | SZ2975000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | II |
| H.S.code* | 2933.99-000 |
Application
Thiotepa: An Alkylating Cytotoxic Agent with a Broad Spectrum of Antitumor Activity
Thiotepa (ThioTEPA) is a trifunctional alkylating cytotoxic agent with a broad spectrum of antitumor activity. It is thought to inhibit tumor growth by inhibiting DNA synthesis.1) The major DNA bond cleavages are initiated by alkylation of guanine and adenine at the N-7 position, which breaks the bond between the purine base and the sugar, releasing alkylated guanines and adenines.2) (The product is for research purpose only.)
References
- 1) Chemistry, pharmacology and pharmacokinetics of N,N',N" - triethylenethiophosphoramide triethylenethiophosphoramide (ThioTEPA) (a review)
- 2) Density Functional Theory Investigation of the Binding of ThioTEPA to Purine Bases: Thermodynamics and Bond Evolution Theory Analysis
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