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CAS RN: 162011-90-7 | Product Number: R0206
Rofecoxib
Purity: >98.0%(GC)
Synonyms:
- 4-[4-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
Product Documents:
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Product Number | R0206 |
Purity / Analysis Method | >98.0%(GC) |
Molecular Formula / Molecular Weight | C__1__7H__1__4O__4S = 314.36 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
Packaging and Container | 250MG-Glass Bottle with Plastic Insert (View image) |
CAS RN | 162011-90-7 |
Reaxys Registry Number | 8269007 |
PubChem Substance ID | 354335586 |
Merck Index (14) | 8248 |
MDL Number | MFCD00935806 |
Specifications
Appearance | White to Yellow to Orange powder to crystal |
Purity(GC) | min. 98.0 % |
Melting point | 207.0 to 211.0 °C |
NMR | confirm to structure |
Properties (reference)
Melting Point | 209 °C |
Solubility in water | Insoluble |
Degree of solubility in water | 472 mg/l 25 °C |
Solubility (slightly sol. in) | Methanol |
GHS
Pictogram | |
Signal Word | Warning |
Hazard Statements | H302 : Harmful if swallowed. |
Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
RTECS# | LU5135000 |
Transport Information:
H.S.code* | 2932.20-000 |
Application
Rofecoxib: A Selective Cyclooxygenase-2 (COX-2) Inhibitor
Rofecoxib is a non-steroidal anti-inflammatory drug (NSAID), and a selective cyclooxygenase-2 (COX-2) inhibitor. The mechanism of action is mainly by inhibition of the enzyme COX in the arachidonic acid metabolism pathway, resulting in reduced prostaglandin synthesis. In theory, a drug that selectively inhibited COX-2 might block inflammation, pain, and fever produced by prostaglandins while reducing the side effects (gastric erosions and ulcers) associated with inhibition of COX-1. For your reference, rofecoxib was withdrawn from the medicine market in 2004 after it was shown that long-term clinical use could increase the risk of heart attack and stroke. (The product is for research purpose only.)
References
- The discovery of rofecoxib, [MK 966, Vioxx®, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2 inhibitor
- Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles
- Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis
- Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention Trial
- Progress in COX-2 inhibitors: a journey so far (a review)
- Determination of rofecoxib, a cyclooxygenase-2 specific inhibitor, in human plasma using high-performance liquid chromatography with post-column photochemical derivatization and fluorescence detection
- Review of the applications of different analytical techniques for coxibs research (a review)
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