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CAS RN: 503468-95-9 | Product Number: N1110
NU 7441
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Purity: >98.0%(HPLC)
Synonyms:
- KU 57788
- 8-(Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-one
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
$180.00
|
10 | 4 | It can be shipped in about 3-4 weeks after ordering | |
| 50MG |
$271.00
|
10 | 11 | It can be shipped in about 3-4 weeks after ordering |
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to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
Supplemental Product Information:
This product is unavailable in the U.S.
| Product Number | N1110 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__5H__1__9NO__3S = 413.49 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 10MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 503468-95-9 |
| Reaxys Registry Number | 9876245 |
| MDL Number | MFCD11983069 |
Specifications
| Appearance | White to Gray to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 3.00 to 3.80 % |
Properties (reference)
| Melting Point | 222 °C(dec.) |
| Maximum Absorption Wavelength | 233 nm (EtOH) |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2934.99-000 |
Application
CRISPR Genome Editing
DNA-dependent protein kinase (DNA-PK) inhibitor, NU 7441, reduces the frequency of non-homologous end joining (NHEJ) while increasing the rate of homology-directed recombination (HDR) following Cas9-mediated DNA cleavage.1)
References
- 1) Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing
Application
NU7441: DNA-dependent protein kinase (DNA-PK) inhibitor
Recently, the inhibition of DNA repair is emerging as a new therapeutic strategy for cancer treatment. NU7441 (KU57788) is a potent and selective inhibitor of the DNA repair enzyme DNA-dependent protein serine/threonine kinase (DNA-PK) which is activated by DNA damage and mediates DNA double-strand break repair. (The product is for research purpose only.)
References
- Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries
- Discovery of Potent Chromen-4-one Inhibitors of the DNA-Dependent Protein Kinase (DNA-PK) Using a Small-Molecule Library Approach
- Preclinical Evaluation of a Potent Novel DNA-Dependent Protein Kinase Inhibitor NU7441
- DNA-Dependent Protein Kinase Is a Therapeutic Target and an Indicator of Poor Prognosis in B-Cell Chronic Lymphocytic Leukemia
- Further characterisation of the cellular activity of the DNA-PK inhibitor, NU7441, reveals potential cross-talk with homologous recombination
Articles/Brochures
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