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CAS RN: 521984-48-5 | Product Number: I1110
SIS 3 Hydrochloride
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Purity: >98.0%(HPLC)
Synonyms:
- (E)-1-[6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl]-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one Hydrochloride
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 5MG |
$210.00
|
14 | Contact Us |
| 25MG |
$730.00
|
17 | Contact Us |
* Please contact our distributors or
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to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | I1110 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__8H__2__7N__3O__3·HCl = 490.00 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic,Heat Sensitive |
| CAS RN | 521984-48-5 |
| PubChem Substance ID | 468592101 |
| MDL Number | MFCD09265258 |
Specifications
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
Transport Information:
| H.S.code* | 2933.49-000 |
Application
SIS3 Hydrochloride: a specific inhibitor of Smad3
SIS3 hydrochloride is a specific inhibitor of Smad3 which has been reported as a key downstream effector of transforming growth factor-β (TGF-β) signaling in tissue fibrogenesis, and a key player in progression of fibrosis. Therefore, SIS3 has been expected as an agent for the treatment of fibrosis. (The product is for research purpose only.)
References
- Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-β1-induced extracellular matrix expression
- The preventive and therapeutic implication for renal fibrosis by targetting TGF-β/Smad3 signaling
- SIS3, a specific inhibitor of smad3, attenuates bleomycin-induced pulmonary fibrosis in mice
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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