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CAS RN: 85801-02-1 | Product Number: I0943
Indometacin Farnesil
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 100MG |
$394.00
|
6 | 1 |
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| Product Number | I0943 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__3__4H__4__0ClNO__4 = 562.15 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 85801-02-1 |
| PubChem Substance ID | 354333527 |
| MDL Number | MFCD00870661 |
Specifications
| Appearance | Light yellow to Yellow to Orange clear liquid |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 2.00 to 3.00 % |
| NMR | confirm to structure |
Properties (reference)
| Flash point | 333 °C |
| Solubility in water | Insoluble |
| Solubility (slightly sol. in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | NL3522820 |
Transport Information:
| H.S.code* | 2933.99-000 |
Application
Indometacin Farnesil: A Prodrug of the Non-Steroidal Anti-Inflammatory Drug Indomethacin
Indometacin farnesil is a prodrug of the non-steroidal anti-inflammatory drug (NSAID) indomethacin [I0655], designed to reduce the occurrence of side-effects in the gastrointestinal tract. When indometacin farnesil is administered orally, it is absorbed through the gastrointestinal tract as unchanged drug which is mildly injurious to the tract. Indometacin farnesil is metabolized to indomethacin, the active form, in the liver and kidney, and this indomethacin inhibits prostaglandin biosynthesis by inhibiting cyclooxygenase (COX). (The product is for research purpose only.)
References
- Inhibitory effect of indomethacin farnesil, a novel antiinflammatory prodrug, on carrgeenin-induced inflammation in rats
- Metabolic fate of indomethacin farnesil, a prodrug of indomethacin: characteristic biotransformation of indomethacin farnesil in rats
- Ulcerogenicity and effect on inhibition of prostaglandin generation of indometacin farnesil, a prodrug of indomethacin, in rat gastric mucosa: comparison with indomethacin or loxoprofen
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