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CAS RN: 30652-11-0 | Product Number: H0944
3-Hydroxy-1,2-dimethyl-4(1H)-pyridone
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Purity: >98.0%(GC)(T)
Synonyms:
- Deferiprone
Product Documents:
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| 5G |
$47.00
|
15 | ≥100 | Contact Us | |
| 25G |
$149.00
|
34 | 2 | Contact Us |
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| Product Number | H0944 |
| Purity / Analysis Method | >98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__7H__9NO__2 = 139.15 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 30652-11-0 |
| Reaxys Registry Number | 1447108 |
| PubChem Substance ID | 87571300 |
| SDBS (AIST Spectral DB) | 16851 |
| Merck Index (14) | 2859 |
| MDL Number | MFCD00134497 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Solubility in Acetic acid | almost transparency |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 260 °C(dec.) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | UU7785940 |
Transport Information:
| H.S.code* | 2933.39-000 |
Application
Mitophagy research
References
- Loss of iron triggers PINK1/Parkin-independent mitophagy
- PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
Application
Deferiprone: A Potent Chelating Agent with an Affinity for Ferric Ion [Fe (III)]
Deferiprone is a potent chelating agent with an affinity for ferric ion [Fe (III)]. Reportedly, deferiprone binds with ferric ions to form neutral 3:1 (deferiprone:iron) complexes that are stable over a wide range of pH values. And then, deferiprone has a lower binding affinity for other metals such as copper, aluminum and zinc than for iron. Deferiprone, an iron chelator that may cross the blood-brain barrier, is used therapeutically in conditions of transfusional iron overload and Friedreich's ataxia (FRDA) for the excretion of iron. (The product is for research purpose only.)
References
- Role of deferiprone in chelation therapy for transfusional iron overload (a review)
- Oral chelators Deferasirox and Deferiprone for transfusional iron overload in thalassemia major: new data, new questions
- Deferiprone for the treatment of Friedreich's ataxia
- Chromatography of 3-hydroxypyridin-4-ones: novel orally active iron chelators
- Development of a fast LC-MS/MS assay for the determination of deferiprone in human plasma and application to pharmacokinetics
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