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CAS RN: 333717-40-1 | Product Number: E1306

O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium Hexafluorophosphate


Purity: >98.0%(HPLC)(N)
Synonyms:
  • HOTU
Product Documents:
1G
$28.00
2   9   Contact Us
5G
$89.00
4   3   Contact Us

* Please contact our distributors or TCI to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.


Product Number E1306
Purity / Analysis Method >98.0%(HPLC)(N)
Molecular Formula / Molecular Weight C__1__0H__1__7F__6N__4O__3P = 386.24 
Physical State (20 deg.C) Solid
Storage Temperature Refrigerated (0-10°C)
Condition to Avoid Heat Sensitive
CAS RN 333717-40-1
Reaxys Registry Number 20028743
PubChem Substance ID 354335078
MDL Number

MFCD01862832

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 98.0 %
Melting point 129.0 to 133.0 °C
NMR confirm to structure
Properties (reference)
Melting Point 132 °C
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P270 : Do not eat, drink or smoke when using this product.
P271 : Use only outdoors or in a well-ventilated area.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell.
P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell.
Related Laws:
Transport Information:
H.S.code* 2928.00-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
Condensing Agent with Less Epimerization

Experimental procedure: HOTU (0.25 mmol) is added to a mixture of Cbz-Phe-OH (0.25 mmol), H-Ala-OCH3·HCl (0.25 mmol) and N-methylmorpholine (0.75 mmol) in dry acetonitrile (5 mL) at 0 °C. The reaction mixture is stirred at the same temperature for 1 h and then at room temperature for 2 h. EtOAc (50 mL) is added and the mixture is subsequently washed with 10% aqueous HCl (v/v), saturated aqueous Na2CO3 and saturated aqueous NaCl solution (2 × 10 mL). Finally, the organic solvent is dried with anhydrous Na2SO4, filtered, and the solvent is removed under reduced pressure. The gummy residue is dried under vacuum to obtain 1 (> 99% yield, DL < 1%).

References


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