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CAS RN: 298-57-7 | Product Number: C3459
Cinnarizine
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Purity: >98.0%(HPLC)(N)
Synonyms:
- 1-Cinnamyl-4-diphenylmethylpiperazine
- 1-(Diphenylmethyl)-4-(3-phenyl-2-propenyl)piperazine
- 1-Benzhydryl-4-cinnamylpiperazine
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10G |
$53.00
|
29 | 4 | Contact Us | |
| 50G |
$156.00
|
5 | 1 | Contact Us |
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* The storage conditions are subject to change without notice.
| Product Number | C3459 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__2__6H__2__8N__2 = 368.52 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 298-57-7 |
| Reaxys Registry Number | 626120 |
| PubChem Substance ID | 354335235 |
| Merck Index (14) | 2305 |
| MDL Number | MFCD00056037 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 117.0 to 121.0 °C |
Properties (reference)
| Melting Point | 119 °C |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2933.59-000 |
Application
Cinnarizine: A Calcium Channel and a Histamine H1 Receptor Antagonist
Cinnarizine, a piperazine derivative, is a calcium channel and a histamine H1 receptor antagonist. Cinnarizine inhibits contractions of vascular smooth muscle cells by blocking calcium channels. In addition, cinnarizine increases erythrocyte deformability and decreases blood viscosity. Cinnarizine also exhibits anticonvulsant properties. Cinnarizine is used widely in the treatment of circulatory disorders. However, cinnarizine-induced parkinsonism has been reported. (The product is for research purpose only.)
References
- Flunarizine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use
- Effects of cinnarizine, a calcium antagonist that produces human parkinsonism, in parkin knock out mice
- Oral bioavailability of cinnarizine in dogs: Relation to SNEDDS droplet size, drug solubility and in vitro precipitation
- Simultaneous determination of cinnarizine and domepiridone maleate from tablet dosage form by reverse phase ion pair high performance liquid chromatography
- Validation of a solid-phase extraction and liquid chromatography-electrospray tandem mass spectrometric method for the determination of nine basic pharmaceuticals in wastewater and surface water samples
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