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CAS RN: 58207-19-5 | Product Number: C2256
Clindamycin Hydrochloride Monohydrate
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
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| 5G |
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| 25G |
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| Product Number | C2256 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__3__3ClN__2O__5S·HCl·H__2O = 479.46 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 58207-19-5 |
| Related CAS RN | 21462-39-5&18323-44-9 |
| Reaxys Registry Number | 4070786 |
| PubChem Substance ID | 87560446 |
| SDBS (AIST Spectral DB) | 52371 |
| Merck Index (14) | 2356 |
| MDL Number | MFCD06411091 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation | +140 to +147 deg(C=2, H2O)(calcd.on anh.substance) |
| Water | 3.0 to 6.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 143 °C |
| Specific Rotation | 143° (C=2,H2O) |
GHS
Related Laws:
| RTECS# | GF2275000 |
Transport Information:
| H.S.code* | 2941.90-000 |
Application
Clindamycin Hydrochloride: A Semisynthetic Lincosamide Antibiotic with Strong Activity against Anaerobic Bacteria
Clindamycin (7-chloro-lincomycin) hydrochloride is a semisynthetic lincosamide antibiotic derivative of lincomycin [L0166] to replace the 7-hydroxy group with a chlorine atom with inversion of chirality. Clindamycin is usually more active than lincomycin, in particular against anaerobic bacteria. It has broad activity against anaerobic Gram-positive bacteria and anaerobic Gram-negative bacteria with a few exceptions, but less activity against most aerobic Gram-negative bacteria. Clindamycin is also effective in treating Plasmodium falciparum malaria. Clindamycin interacts with the 50s subunit of bacterial ribosomes, and then it inhibits bacterial growth by inhibiting protein synthesis. Bacterial resistance to clindamycin and lincomycin may be caused by methylation of bacterial 23S ribosomal RNA. Clindamycin phosphate [C2257] is a prodrug of clindamycin, and is designed as a highly water soluble form of the poorly water soluble parent compound clindamycin.
References
- Clindamycin hydrochloride (a review)
- Clindamycin, metronidazole, and chloramphenicol (a review)
- Lincomycin, clindamycin and their applications (a review)
- Clindamycin as an antimalarial drug: review of clinical trials
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