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CAS RN: 68123-33-1 | Product Number: A5522
N-Succinimidyl 4-Nitrophenylacetate [for HPLC Labeling]
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![N-Succinimidyl 4-Nitrophenylacetate [for HPLC Labeling]](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "N-Succinimidyl 4-Nitrophenylacetate [for HPLC Labeling]")
Purity: >98.0%(N)
Synonyms:
- N-(4-Nitrophenylacetoxy)succinimide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
$125.00
|
8 | 13 | Contact Us |
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| Product Number | A5522 |
| Purity / Analysis Method | >98.0%(N) |
| Molecular Formula / Molecular Weight | C__1__2H__1__0N__2O__6 = 278.22 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 68123-33-1 |
| Reaxys Registry Number | 6228910 |
| PubChem Substance ID | 87563163 |
| SDBS (AIST Spectral DB) | 11057 |
| MDL Number | MFCD00047124 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 181.0 to 185.0 °C |
| Solubility in hot Acetone | almost transparency |
| Effect test of HPLC derivatization | Effective as labeling agent for Ｄiethylamine. |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 181 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| H.S.code* | 2925.19-000 |
Application
HPLC Labeling Reagent for Amines
The compound 1 is an HPLC labeling reagent, which has a succinimidyl group, which can easily react with an amino group to form the corresponding amide derivative. The resultant amide is stable enough to reach the detector without any decomposition under reversed phase HPLC. An excellent chromatogram can be obtained by measuring at 254 nm, an absorption wavelength that is generally used for UV detection.
Application examples:
[Alkylamines]
1~5 mg of a sample (free amine), 5 mL of THF, and 50 mg of labeling reagent 1 are mixed, and incubated at 60°C for 1 h. After cooling to room temperature, use it as an HPLC sample. If it is necessary to remove the unreacted labeling reagent and by-product, N-hydroxysuccinimide, evaporate the solvent at a low temperature under a nitrogen atmosphere. Dissolve the residue in 2~3 mL of ether and wash with aqueous NaHCO3 and water.
[Others]
Drugs (amphetamine, methamphetamine)1)
[Alkylamines]
1~5 mg of a sample (free amine), 5 mL of THF, and 50 mg of labeling reagent 1 are mixed, and incubated at 60°C for 1 h. After cooling to room temperature, use it as an HPLC sample. If it is necessary to remove the unreacted labeling reagent and by-product, N-hydroxysuccinimide, evaporate the solvent at a low temperature under a nitrogen atmosphere. Dissolve the residue in 2~3 mL of ether and wash with aqueous NaHCO3 and water.
[Others]
Drugs (amphetamine, methamphetamine)1)
TCI Products Pamphlet
HPLC Labeling Reagents ( PDF 10MB )
HPLC Labeling Reagents ( PDF 10MB )
References
- 1)T. H. Jupille, Am. Lab. 1976, 8, 85.
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