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CAS RN: 20235-78-3 | Product Number: T4108
2-Thiouridine
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Purity: >98.0%(HPLC)(qNMR)
Synonyms:
- 1-β-D-Ribofuranosyl-2-thiouracil
- 1-β-D-Ribofuranosyl-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone
- 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
$137.00
|
31 | 0 | Contact Us |
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| Product Number | T4108 |
Purity / Analysis Method 
|
>98.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__9H__1__2N__2O__5S = 260.26 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 20235-78-3 |
| Reaxys Registry Number | 28752 |
| MDL Number | MFCD03788697 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(qNMR) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 215 °C |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2934.99-000 |
Application
Sulfur-modified Nucleoside: Thiouridines
References
- Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP
- Thermodynamics of RNA−RNA Duplexes with 2- or 4-Thiouridines: Implications for Antisense Design and Targeting a Group I Intron
- Synthesis and studies on the effect of 2-thiouridine and 4-thiouridine on sugar conformation and RNA duplex
- Biosynthesis and functions of sulfur modifications in tRNA (a review)
- Transfer RNA modification: presence, synthesis, and function (a review)
- Replacing Uridine with 2-Thiouridine Enhances the Rate and Fidelity of Nonenzymatic RNA Primer Extension
- Thermodynamic insights into 2-thiouridine-enhanced RNA hybridization
Application
2-Thiouridine: A Sulfur-Containing Thioribonucleoside Found in tRNA
2-Thiouridine (s2U) is a sulfur-containing thioribonucleoside found in tRNA. Thioribonucleosides have been reported to perform essential functions for accurate and efficient translation, including proper codon recognition in mRNA or stabilization of tRNA structure. In addition, 2-thiouridine is stabilizes U:A pairs and destabilizes U:G wobble pairs. Thus, thioribonucleosides, including 2-thiouridine, are used to study nucleic acid structure and function.
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