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CAS RN: 82956-11-4 | Product Number: N0959
Nafamostat Mesylate
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Purity: >98.0%(HPLC)
Synonyms:
- 6-Amidino-2-naphthyl 4-Guanidinobenzoate Bis(methanesulfonate)
- 4-Guanidinobenzoic Acid 6-Amidino-2-naphthyl Ester Bis(methanesulfonate)
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 20MG |
$39.00
|
≥40 | ≥60 |
| 100MG |
$135.00
|
≥40 | ≥100 |
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* The storage conditions are subject to change without notice.
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | N0959 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__1__7N__5O__2·2CH__4O__3S = 539.58 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 82956-11-4 |
| Related CAS RN | 81525-10-2 |
| Reaxys Registry Number | 5703937 |
| PubChem Substance ID | 253661919 |
| Merck Index (14) | 6350 |
| MDL Number | MFCD00941430 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
Properties (reference)
| Melting Point | 258 °C |
| Solubility in water | Soluble |
| Solubility (insoluble in) | Ether, Acetone |
GHS
Related Laws:
| RTECS# | DG2736000 |
Transport Information:
| H.S.code* | 2925.29-000 |
Application
セリンプロテアーゼ阻害剤，ナファモスタットメシル酸塩
Nafamostat mesilate was first reported by Fujii and Hitomi in 1981 as a synthetic serine protease inhibitor. This compound inhibits various serine protease generated during the coagulation cascade and the inflammatory process. Nafamostat mesilate has been commonly used as an anticoagulant and reported as a drug for the treatments of DIC (disseminated intravascular coagulation) and acute pancreatitis and as an anticoagulant in extracorporeal circulation. (The product is for research purpose only.)
References
- New synthetic inhibitors of C1r, C1 esterase, thrombin, plasmin, kallikrein and trypsin.
- Pharmacological studies of FUT-175, nafamstat mesylate. I. Inhibition of protease activity in in vitro and in vivo experiments
- Nafamostat mesilate (a review)
- Potent pruritogenic action of tryptase mediated by PAR-2 receptor and its involvement in anti-pruritic effect of nafamostat mesilate in mice
- Involvement of human blood arylesterases and liver microsomal carboxylesterases in nafamostat hydrolysis
PubMed Literature
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