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CAS RN: 59880-97-6 | Product Number: F1158
N-Formyl-L-methionyl-L-leucyl-L-phenylalanine
Purity: >98.0%(HPLC)
Synonyms:
- N-Formyl-Met-Leu-Phe
- fMLF
- fMLP
Product Documents:
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Product Number | F1158 |
Purity / Analysis Method | >98.0%(HPLC) |
Molecular Formula / Molecular Weight | C__2__1H__3__1N__3O__5S = 437.56 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Frozen (<0°C) |
Condition to Avoid | Heat Sensitive |
Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image) |
CAS RN | 59880-97-6 |
Reaxys Registry Number | 2315783 |
PubChem Substance ID | 468591830 |
MDL Number | MFCD00036780 |
Specifications
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Specific rotation [a]20/D | -8.0 ~ -10.0 deg(C=1, acetic acid) |
Properties (reference)
Melting Point | 213 °C(dec.) |
Specific Rotation | -8° (C=1,AcOH) |
GHS
Related Laws:
Transport Information:
H.S.code* | 2930.90-900 |
Application
fMLP: A Highly Potent Leukocyte Chemoattractant
N-Formyl-Met-Leu-Phe (abbrev.: fMLP or FMLP), a bacterial peptide, is a highly potent leukocyte chemoattractant. It is a powerful "activators" of polymorphonuclear and mononuclear phagocytes. Its specific receptors have been identified on neutrophil plasma membrane which plays an important role in host defense against bacterial infections.
References
- Cellular responses to FMLP challenging: a mini-review
- Signal transduction pathways triggered by selective formylpeptide analogues in human neutrophils (a review)
- Studies on human neutrophil biological functions by means of formyl-peptide receptor agonists and antagonists (a review)
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