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CAS RN: 88321-09-9 | Product Number: E1337
E-64d [for Biochemical Research]
![Thumbnail of E-64d [for Biochemical Research]](/medias/E1337.jpg?context=bWFzdGVyfHJvb3R8MTMwMDB8aW1hZ2UvanBlZ3xhR0ZpTDJnMVl5ODRPVE0xTURnNU9UWXpNRE00TDBVeE16TTNMbXB3Wnd8ZTI0NGQ2OGY2YzI2MzcwYTBiYmY5ZjM1MTI3ODlmYjAxYmY0ZmE0Y2EwMzRiMjE2ZGExNzA0YmViM2UwNjFhNw "E-64d [for Biochemical Research]")
![Chemical Structure of E-64d [for Biochemical Research]](/medias/E1337.jpg?context=bWFzdGVyfHJvb3R8NDAzNjZ8aW1hZ2UvanBlZ3xhRFUwTDJobFpDODRPVEl4TmpZMk9UUTFNRFUwTDBVeE16TTNMbXB3Wnd8ZmQwZDliNWYyNWRlNjg2MjU5ZjAzZWFiMzdmNTVlMDMyNGZhNzNmMWI3NGJmZDRhZWE1YjQwOGI3N2ZmMmNjNA "E-64d [for Biochemical Research]")
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![E-64d [for Biochemical Research]](/_ui/responsive/theme-tci/images/missing_product_zoom.webp "E-64d [for Biochemical Research]")
Purity: >95.0%(HPLC)
Synonyms:
- Loxistatin
- Ethyl (2S,3S)-3-[[(2S)-4-Methyl-1-[(3-methylbutyl)amino]-1-oxo-2-pentanyl]carbamoyl]-2-oxiranecarboxylate
- (2S,3S)-3-[[(2S)-4-Methyl-1-[(3-methylbutyl)amino]-1-oxo-2-pentanyl]carbamoyl]-2-oxiranecarboxylic Acid Ethyl Ester
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 5MG |
$104.00
|
18 | 6 | It can be shipped in about 2 weeks after ordering | |
| 25MG |
$355.00
|
3 | 8 | It can be shipped in about 2 weeks after ordering |
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to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | E1337 |
Purity / Analysis Method 
|
>95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__3__0N__2O__5 = 342.44 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 88321-09-9 |
| Reaxys Registry Number | 5354546 |
| PubChem Substance ID | 468591716 |
| MDL Number | MFCD00132883 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Specific rotation [a]20/D | +48.0 to +53.0 deg(C=1, EtOH) |
Properties (reference)
| Melting Point | 126 °C |
| Specific Rotation | 49° (C=1,MeOH) |
GHS
Related Laws:
| RTECS# | RR0404300 |
Transport Information:
| H.S.code* | 2924.29-000 |
Application
E-64d: A Potent and Irreversible Cysteine Protease Inhibitor
Cysteine proteases are enzymes containing nucleophilic cysteine thiol that are important in protein degradation pathway. E-64d (loxistatin) is a cell-permeable ethyl ester of E-64c which is a potent and irreversible cysteine protease inhibitor.
References
- In vitro and in vivo inhibition of cysteine proteinases by EST, a new analog of E-64
- Thiol protease-specific inhibitor E-64 arrests human epidermoid carcinoma A431 cells at mitotic metaphase
- Determination of a cysteine protease inhibitor and its ethyl ester in mouse serum and muscle by liquid chromatography-mass spectrometry
- プロテアーゼインヒビターとプロドラッグデザイン
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