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CAS RN: 113-59-7 | Product Number: C3505
Chlorprothixene
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Purity: >98.0%(T)
Synonyms:
- (Z)-3-(2-Chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-1-propanamine
- (Z)-2-Chloro-9-(3-dimethylaminopropylidene)thioxanthene
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 250MG |
$19.00
|
9 | 0 | Contact Us | |
| 1G |
$59.00
|
3 | 0 | Contact Us | |
| 5G |
$205.00
|
2 | 1 | Contact Us |
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* The storage conditions are subject to change without notice.
| Product Number | C3505 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__1__8H__1__8ClNS = 315.86 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image), 250MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 113-59-7 |
| Reaxys Registry Number | 9208755 |
| PubChem Substance ID | 354335789 |
| Merck Index (14) | 2188 |
| MDL Number | MFCD00869180 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(GC) | min. 97.0 % |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 95.0 to 99.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 97 °C |
| Maximum Absorption Wavelength | 324 nm (CH__3CN) |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Ether, Alcohol, Chloroform, Methanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | XO1050000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2934.99-000 |
Application
Chlorprothixene: A Non-Selective Dopamine and 5-Hydroxytryptamine Receptor Antagonist
Chlorprothixene is a thioxanthene neuroleptic used as a typical antipsychotic agent. Reportedly, it works as a non-selective dopamine and 5-hydroxytryptamine (5-HT) receptor antagonist. (The product is for research purpose only.)
References
- Receptor activity and turnover of dopamine and noradrenaline after neuroleptics
- Biologically active conformers of phenothiazines and thioxanthenes. Further evidence for a ligand model of dopamine D2 receptor antagonists
- Effects of chlorprothixene isomers on platelet 5-hydroxytryptamine receptors: evidence for different 5-hydroxytryptamine conformations at uptake and stimulatory sites
- Chlorprothixene [2-chloro-N,N-dimethylthioxanthene-Δ9,γ-propylamine] (a review on the physical properties, synthesis, stability-degradation, drug metabolic products, and methods of analysis.)
- Separation of cis- and trans-isomers of thioxanthene and dibenz[b,e]oxepin derivatives on calixarene- and resorcinarene-bonded high-performance liquid chromatography stationary phases
Application
Chlorprothixene: A Classical Thioxanthene Typical Antipsychotic Agent
Chlorprothixene is a classical thioxanthene typical antipsychotic agent. The mode of action of the thioxanthenes currently not clear, but its dopamine antagonism has been reported. (The product is for research purpose only.)
References
- Pharmacological specificity of conditioned avoidance response inhibition in rats: inhibition by neuroleptics and correlation to dopamine receptor blockade
- Biologically active conformers of phenothiazines and thioxanthenes. Further evidence for a ligand model of dopamine D2 receptor antagonists
- Chlorprothixene (A review on the physical properties, synthesis, stability-degradation, drug metabolic products, and methods of analysis of chlorprothixene)
- Separation of cis- and trans-isomers of thioxanthene and dibenz[b,e]oxepin derivatives on calixarene- and resorcinarene-bonded high-performance liquid chromatography stationary phases
- Detection of antidepressant and antipsychotic drugs in human hair
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