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CAS RN: 1492-18-8 | Product Number: C2235
Calcium Folinate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- Folinic Acid Calcium Salt
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 1G |
$80.00
|
6 | 7 |
| 5G |
$236.00
|
6 | ≥40 |
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* The storage conditions are subject to change without notice.
| Product Number | C2235 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__1CaN__7O__7 = 511.51 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Hygroscopic |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 1492-18-8 |
| Related CAS RN | 58-05-9&6035-45-6&2060570-47-8 |
| Reaxys Registry Number | 5723924 |
| PubChem Substance ID | 87560126 |
| MDL Number | MFCD00006704 |
Specifications
| Appearance | Light orange to Yellow to Green powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Chelometric Titration) | min. 98.0 %(calcd.on anh.substance) |
| Water | max. 17.0 % |
| NMR | confirm to structure |
Properties (reference)
| Solubility in water | Soluble |
| Solubility (insoluble in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | MA0600500 |
Transport Information:
| H.S.code* | 2934.99-000 |
Application
Calcium folinate: a Pharmaceutical Adjuvant for Folate Antagonists and 5-Fluorouracil
Calcium folinate is used as to reduce the harmful effects of folate antagonists such as methotrexate [M1664]. Calcium folinate is also used in synergistic combination with 5-fluorouracil [F0151] to enhance of its antitumor effect.
References
- Folate supplementation and methotrexate treatment in rheumatoid arthritis: a review
- Effect of folic or folinic acid supplementation on methotrexate-associated safety and efficacy in inflammatory disease: a systematic review
- Enhancement of the antitumor effects of 5-fluorouracil by folinic acid
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