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CAS RN: 485-49-4 | Product Number: B1890
(+)-Bicuculline
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 25MG |
$41.00
|
9 | ≥40 | Contact Us | |
| 100MG |
$124.00
|
5 | 13 | Contact Us |
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* The storage conditions are subject to change without notice.
| Product Number | B1890 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__1__7NO__6 = 367.36 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image), 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 485-49-4 |
| Reaxys Registry Number | 98786 |
| PubChem Substance ID | 125308663 |
| SDBS (AIST Spectral DB) | 16661 |
| Merck Index (14) | 1203 |
| MDL Number | MFCD00005006 |
Specifications
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 195.0 to 199.0 °C |
| Specific rotation [a]20/D | +127.0 to +132.0 deg(C=1, CHCl3) |
Properties (reference)
| Melting Point | 197 °C |
| Specific Rotation | 132° (C=1,CHCl3) |
| Maximum Absorption Wavelength | 325 nm |
| Solubility (soluble in) | Benzene |
| Solubility (slightly sol. in) | Chloroform |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled. H401 : Toxic to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing. P361 + P364 : Take off immediately all contaminated clothing and wash it before reuse. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P311 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
Related Laws:
| RTECS# | LV0909840 |
Transport Information:
| UN Number | UN1544 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2939.79-000 |
Application
Reagents convulsion or paralysis model
References
- Effects of carbamazepine on bicuculline- and pentylenetetrazol-induced seizures in developing rats
- Diazepam prophylaxis for bicuculline-induced seizures: a rat dose-response model
- Pathogenesis of brain lesions caused by experimental epilepsy. Light- and electron-microscopic changes in the rat cerebral cortex following bicuculline-induced status epilepticus
- Local perfusion of diazepam attenuates interictal and ictal events in the bicuculline model of epilepsy in rats
- Cannabinoid suppressed bicuculline-induced convulsion without respiratory depression in the brainstem-spinal cord preparation from newborn rats
Application
GABA Receptor Antagonist
GABA (γ-aminobutyric acid) is the main inhibitory neurotransmitter in the mammalian central nerve system and GABAA, GABAB, and GABAC receptors have been identified as the major receptors.1) GABAA and GABAC receptors are members of transmitter-gated ion channels, and GABAB receptors are the receptors that are coupled to G-protein and activate secondary messenger systems and Ca2+ and K+ ion channels.1)
Bicuculline (1) is a phthalide isoquinoline alkaloid isolated from a variety of plants, Dicentra, Corydalis, and Adlumia, genera of the Fumariaceae family. GABAA receptors are selectively blocked by 1.1-3) Affinity of 1 and the receptors have been studied by using mutational forms of recombinant receptor proteins.3) 1 and its quaternary salts also have actions other than as GABA-receptor antagonists including inhibition of cholinesterase, effects on 5-HT3, nicotinic, and N-methyl-D-aspartate (NMDA) receptors.2,3)
Bicuculline (1) is a phthalide isoquinoline alkaloid isolated from a variety of plants, Dicentra, Corydalis, and Adlumia, genera of the Fumariaceae family. GABAA receptors are selectively blocked by 1.1-3) Affinity of 1 and the receptors have been studied by using mutational forms of recombinant receptor proteins.3) 1 and its quaternary salts also have actions other than as GABA-receptor antagonists including inhibition of cholinesterase, effects on 5-HT3, nicotinic, and N-methyl-D-aspartate (NMDA) receptors.2,3)
References
- 1)The ‘ABC’ of GABA receptors: a brief review
- 2)Herbal products and GABA receptors
- 3)Advantages of an antagonist: bicuculline and other GABA antagonists
PubMed Literature
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