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CAS RN: 65928-58-7 | Product Number: D5230
Dienogest
×
Purity: >98.0%(HPLC)
Synonyms:
- 17α-17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile
- 17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile
- 17-Cyanomethyl-17-hydroxy-estra-4,9-dien-3-one
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 50MG |
$199.00
|
15 | 1 | Contact Us | |
| 250MG |
$696.00
|
0 | 5 | Contact Us |
* Please contact our distributors or
TCI
to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | D5230 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__5NO__2 = 311.43 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 65928-58-7 |
| Reaxys Registry Number | 5763925 |
| PubChem Substance ID | 354335037 |
| Merck Index (14) | 3106 |
| MDL Number | MFCD00868356 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 213.0 to 217.0 °C |
| Specific rotation [a]20/D | -315 to -325 deg(C=1, CH2Cl2) |
Properties (reference)
| Melting Point | 215 °C |
| Specific Rotation | -307° (C=1,CHCl3) |
| Solubility in water | Insoluble |
| Solubility (slightly sol. in) | Methanol, Acetone |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | RC8899500 |
Transport Information:
| H.S.code* | 2937.23-000 |
Application
Dienogest: A Selective Progesterone Receptor Agonist
Dienogest, a synthetic nortestosterone [N0449] derivative, is a selective progesterone receptor agonist. Although dinogest binds to the progesterone receptor of the human uterus with only 10% of the relative affinity of progesterone, it has a strong progestogenic effect in vivo. In addition, dienogest displays moderate anti-gonadotrophic effects, but no androgenic, glucocorticoid or mineralocorticoid activity in vivo. It is reported that the agonist activity is approximately one third of that of cyproterone acetate [C2942]. Dienogest has been used in the treatment of endometriosis by reducing the endogenous production of estradiol [E0025]. (The product is for research purpose only.)
References
- Dienogest (a review)
- The inhibitory effect of dienogest, a synthetic steroid, on the growth of human endometrial stromal cells in vitro
- Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile
- Validated UPLC method for the fast and sensitive determination of steroid residues in support of cleaning validation in formulation area
- Dienogest: a review of its use in the treatment of endometriosis
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