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CAS RN: 120202-66-6 | Product Number: C2556
(S)-(+)-Clopidogrel Sulfate
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Purity: >98.0%(HPLC)(N)
Synonyms:
- Methyl (S)-(+)-2-(2-Chlorophenyl)-2-[6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]acetate Sulfate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
$140.00
|
≥40 | 7 | It can be shipped in about 3 months after ordering | |
| 5G |
$481.00
|
17 | ≥100 | It can be shipped in about 3 months after ordering |
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| Product Number | C2556 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__6H__1__6ClNO__2S·H__2SO__4 = 419.89 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 120202-66-6 |
| Related CAS RN | 113665-84-2 |
| Reaxys Registry Number | 9967887 |
| PubChem Substance ID | 125308051 |
| MDL Number | MFCD00876395 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Optical Isomer | max. 0.5 % |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Specific rotation [a]20/D | +54.0 to +58.0 deg(C=1, MeOH) |
| NMR | confirm to structure |
Properties (reference)
| Specific Rotation | 56° (C=1,MeOH) |
| Solubility (soluble in) | Methanol |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2934.99-000 |
Application
(S)-(+)-Clopidogrel Sulfate: An Antiplatelet Agent Acting as a P2Y12 ADP Receptor Antagonist
(S)-(+)-Clopidogrel sulfate is a thienopyridine class inhibitor of platelet activation and aggregation through the binding the P2Y12 class of adenosine diphosphate (ADP) receptors on platelets. (S)-(+)-Clopidogrel is must be metabolized by CYP450-2C19 enzymes in liver to produce the thiol active metabolite antagonizes binding irreversibly to the P2Y12 receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation.1-4) On the other hand, the (R)-enantiomer has no antithrombotic activity.5) (S)-(+)-Clopidogrel has been often used in combination with acetylsalicylic acid (aspirin) [A2262] to the treatment of ischemic vascular disease.4) For your reference, [T2770] is a synthetic intermediate of (S)-(+)-clopidogrel. (The product is for research purpose only.)
References
- 1) P2Y12, a New Platelet ADP Receptor, Target of Clopidogrel
- 2) Identification of the platelet ADP receptor targeted by antithrombotic drugs
- 3) Clopidogrel: a review of its use in the prevention of thrombosis
- 4) Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C19 Genotype and Clopidogrel Therapy: 2013 Update
- 5) Developments in the synthesis of the antiplatelet and antithrombotic drug (S)-clopidogrel (a review)
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