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CAS RN: 480-44-4 | Product Number: A3013
Acacetin
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Purity: >98.0%(GC)
Synonyms:
- 5,7-Dihydroxy-4'-methoxyflavone
- Apigenin 4'-Methyl Ether
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 25MG |
$103.00
|
16 | ≥40 |
| 100MG |
$297.00
|
8 | ≥100 |
* Please contact our distributors or
TCI
to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | A3013 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__2O__5 = 284.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic,Heat Sensitive |
| CAS RN | 480-44-4 |
| Reaxys Registry Number | 277879 |
| PubChem Substance ID | 354334663 |
| Merck Index (14) | 13 |
| MDL Number | MFCD00016936 |
Specifications
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(GC) | min. 98.0 % |
Properties (reference)
| Melting Point | 269 °C |
| Maximum Absorption Wavelength | 335(EtOH) nm |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | DJ3002000 |
Transport Information:
| H.S.code* | 2932.99-000 |
Application
Acacetin: An O-Methylated Flavone with Many Biological Activities
Acacetin is an O-methylated flavone in the traditional Chinese medicine Xuelianhua and many plants as a bioactive compound. Recently, the biological properties of acacetin have been reported, such as anti-peroxidative, anti-inflammatory and anti-cancer effects, and etc. For example, acacetin can show to induce G2/M cell-cycle arrest in human colon cancer cell lines. Acacetin can also suppress ultrarapid delayed rectifier K+ current and other cardiac ionic currents, so preventing atrial fibrillation in an atrium-selective way. (The product is for research purpose only.)
References
- Metabolism of apigenin and related compounds in the rat. Metabolite formation in vivo and by the intestinal microflora in vitro
- Acacetin suppressed LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice
- Individual and interactive effects of apigenin analogs on G2/M cell-cycle arrest in human colon carcinoma cell lines
- Acacetin-induced apoptosis of human breast cancer MCF-7 cells involves caspase cascade, mitochondria-mediated death signaling and SAPK/JNK1/2-c-jun activation
- Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs
- Column-switching high-performance liquid chromatographic assay for determination of apigenin and acacetin in human urine with ultraviolet absorbance detection
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