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FITC dextran (fluorescein isothiocyanate-labeled dextran) is a pH-dependent lysosomal probe1,2) and has been applied to the visualization of lysosomes.3-5) FITC dextran has been used for studies on endocytic processes not only in mammal but also in yeast.6,7)
Lysosomal storage disorders (LSDs), which are defects in the lysosomal enzymes, lead to a progressive accumulation of un-degraded substrates or catabolic products that are unable to escape from the organelle.8) About 50 different clinical entities of LSDs have been genetically identified.9) Recently, the application of FITC dextran extended research for bioconjugates to target lysosomes.10)
The dextran moiety (1) is a FITC-labeled dextran with Mw. = ca. 10,000.
References
1)Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents
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