Published TCIMAIL newest issue No.197
Maximum quantity allowed is 999
Gelieve het aantal te selecteren
Reagent for Preparation of Weinreb Amides
No.153(December 2014)
N-Methoxy-N-methylamides (Weinreb amides) are well known as precursors to site-selective synthesis of unsymmetrical ketones.
In recent years, various synthetic methods for Weinreb amides using N-methoxy-N-methylcarbamoyl chloride (1) have been reported. According to their reports, Weinreb amides are synthesized by the reaction of 1 with organoboronic acids,1) organostannanes,2) Grignard reagents3) and alkylphosphonates,4) respectively.
References
- 1)Palladium-catalyzed preparation of Weinreb amides from boronic acids and N-methyl-N-methoxycarbamoyl chloride
- 2)Palladium-catalyzed coupling reactions of N-methoxy-N-methylcarbamoyl chloride for the synthesis of N-methoxy-N-methylamides
- 3)A novel synthesis of N-methoxy-N-methylamides from 4,6-pyrimidyl urethane and Grignard reagents
- 4)Preparation of [1-(methoxymethylcarbamoyl)ethyl]phosphonic acid bis-(2,2,2-trifluoroethyl)ester: A useful intermediate in the synthesis of Z-unsaturated N-methoxy-N-methylamides
The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.