Published TCIMAIL newest issue No.196
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Chiral Phosphine Ligands: Skewphos Derivatives
Products
These products are commercialized with the cooperation and help from SPERA PHARMA, Inc.
Advantages
- Asymmetric phosphine ligands bearing flexible skeletons
- Possesses different reactivity and selectivity depending on the electron density and steric hindrance of the aryl groups
Applications
Asymmetric hydrogenation of dehydroamino acids 1)
Asymmetric hydrogenation of α-aryl-β-alkylacrylate salts 2)
Related Product Category Pages
References
- 1) Novel chiral water soluble phosphines II. Applications in catalytic asymmetric hydrogenation
- 2) Glucokinase Activator: Practical Asymmetric Hydrogenation and Scalable Synthesis of an API Fragment
