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An Efficient Chiral Organocatalyst for the Cross-aldol Reaction of Aliphatic Ketones with Aldehydes

A proline derived chiral organocatalyst, 1, has been developed by Singh and used for chiral cross-aldol reactions in brine. 1-catalyzed direct cross-aldol reactions are widely applicable to various substances such as aliphatic ketones and α-branched aliphatic aldehydes and afford the desired cross-aldol adducts with high enantioselectivities though it is commonly considered to be difficult to use them for direct cross-aldol reactions. Furthermore, using DMF as a solvent, direct cross-aldol reactions of isobutyraldehyde with linear aldehydes successfully proceed to give the cross-aldol adducts enantioselectively. It is assumed that 1 activates the formyl group by hydrogen bonding with both the NH and OH of the amino alcohol moiety while the two phenyl groups of the catalyst 1 induce the stereoselectivity.

H1407

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