Dess-Martin Oxidation

Dess-Martin oxidation is a mild synthetic method used to convert primary and secondary alcohols to aldehydes and ketones respectively. The principle compound used for this oxidation is Dess-Martin periodinane (DMP), which can be prepared by two-step synthesis from 2-iodobenzoic acid. Dess-Martin oxidation has several advantages over classic Cr(VI)-based oxidation methods including mild conditions, expanded substrate tolerance, reduced environmental impact, and easy handling and workup. Dess-Martin Oxidation is widely used in organic synthesis, including late-stage total synthesis due to the mild nature of the conditions.