Valsartan is a competitive and selective AT
1 receptor antagonist. Valsartan inhibits the actions of angiotensin II at the AT
1 receptor subtype which is responsible for most of the known effects of angiotensin II, a principal pressor agent. Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE). Valsartan blocks the binding of angiotensin II to the AT
1 receptor in many tissues, such as vascular smooth muscle. Recently, the combination of valsartan and a thiazide diuretic hydrochlorothiazide [
H1274] is often use in clinical. (The product is for research purpose only.)