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Published TCIMAIL newest issue No.197
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Bioconjugation
Bioconjugation is the formation of complexes by chemically bonding functional molecules to biomolecules such as DNA, RNA, proteins, lipids and sugars under mild conditions. The bioconjugated complexes are used to develop new methods, for example in drug discovery, ligand binding assays, disease diagnosis, and high-throughput screening. There have been many recent reports of the chemical modification of biomolecules with non-natural bioorthogonal functional groups such as azide.
Well-used Cross-linkers for Antibody-Drug Conjugates (ADC)
Cross-linkers are used in the production of antibody-drug conjugates (ADCs). For example, cross-linkers such as GMBS (Product No. S0399)，EMCS (Product No. S0428), SPDP (Product No. S0819), BMPS (Product No. S0427), and SMCC (Product No. S0853) have been reported, and TCI has synthesized them on a few hundred gram scale.
» Click here for more information about Well-used Cross-linkers for Antibody-Drug Conjugates (ADC).
Enzymatically Cleavable Linkers for Antibody-Drug Conjugates (ADCs)
It has been reported that dipeptides cleaved by enzymes in lysosomes can be used as linkers for antibody-drug conjugates (ADCs). TCI can provide these linkers on a scale of tens of grams.
Copper-free Click Reaction Linkers
The copper(I)-free click reactions proceed with azides and the linkers having a strained structure of cyclooctyne/azacyclooctyne. The set of small volume reagents is also available to save on weighing and to allow each bottle to be used up individually.
» Click here for more information about Copper-free Click Reaction Linkers.
Pre-Weighed Biotinylation Reagents
Biotinylating reagents containing the linker moiety and a NHS ester group react with amino groups (-NH2) in proteins to form amide bonds, enabling biotinylation simply by mixing with proteins. The set consisting of a small volume of the reagent eliminates the need for weighing and allows each bottle to be used up.
» Click here for more information about Pre-Weighed Biotinylation Reagents.
Peroxidase (HRP) Labeling Reagent, Thiol Reactive
This reagent is a peroxidase incorporated with a maleimide group so that it can bind to proteins and peptides containing thiol groups.
» Click here for more information about Peroxidase (HRP) Labeling Reagent, Thiol Reactive.
Other Topics
- Applications for Sugar-conjugate
- Cross-linkers Containing Photoreactive Diazirine Group
- Cross-Linker Containing A Photoreactive Azido Group
- Photo-Cross-Linker Having Benzophenone
- Fluoresceins for Fluorescent Labeling
References
Bioconjugation ReagentsBiotinylation Reagents and AvidinsCross-linkersWell-used Cross-linkers for Antibody-Drug Conjugates (ADC)Protein-maleimide Conjugates for Thiol-maleimide CrosslinkingPre-Weighed Biotinylation ReagentsPeroxidase (HRP) Labeling ReagentsCopper-free Click Reaction ReagentsPhoto-reactive CrosslinkersCross-linker to Stabilize DNA DuplexesNon-PEG Linkers for Designing Proteolysis-Targeting Chimera MoleculesAcrylic Monomers with NHS Ester Moieties for Immobilization to Primary Amino Groups on Tissue SurfacesPre-weighed Bioconjugation ReagentsPhotoreactive Labeling AgentsConjugation Reagents Selectively Reacting with N-Terminal Cysteine ResiduesBifunctional Chelators (BFCs) for Radiopharma Development