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Published TCIMAIL newest issue No.198
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Adenosine Derivative Generated by Biooxidation
8-Oxoadenosine, oxidized at the 8-position of adenosine as in 8-oxoguanosine, is found in RNA as a result of the nucleobase damage caused by reactive oxygen species in vivo. It is thought that such nucleobase damage causes mismatches during DNA replication and inhibition of RNA translation, leading to carcinogenesis, neurodegenerative diseases, and aging. These 8-oxo nucleosides have been considered to be generated in RNA more than in DNA, since DNA is protected by chromatin.1) In the study of the effects of rRNA oxidation on protein synthesis and structural stabilization of RNA, the site-specific introduction of oxidized nucleosides including 8-oxoadenosine into RNA has been reported.2,3)
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References
- 1) Oxidation of Adenosine and Inosine: The Chemistry of 8-Oxo-7,8-dihydropurines, Purine Iminoquinones, and Purine Quinones as Observed by Ultrafast Spectroscopy
- 2) Biophysical properties and thermal stability of oligonucleotides of RNA containing 7,8‐dihydro‐8‐hydroxyadenosine
- 3) Oxidative stress damages rRNA inside the ribosome and differentially affects the catalytic center
