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Published TCIMAIL newest issue No.197
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CAS RN: 38194-50-2 | Product Number: U0099
Sulindac
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (Z)-5-Fluoro-2-methyl-1-[(p-methylsulfinyl)benzylidene]-1H-indene-3-acetic Acid
- (Z)-2-[5-Fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl]acetic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 10G |
112,00 €
|
2 | 7 |
|
| 50G |
357,00 €
|
1 | 7 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | U0099 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__1__7FO__3S = 356.41 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 38194-50-2 |
| PubChem Substance ID | 354334891 |
| Merck Index (14) | 8982 |
| MDL Number | MFCD00599589 |
Specifications
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 182.0 to 186.0 °C |
Properties (reference)
| Melting Point | 184 °C |
| Maximum Absorption Wavelength | 327(0.05mol/L methanolic HCl) nm |
| Solubility in water | Insoluble |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H361 : Suspected of damaging fertility or the unborn child. H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| Precautionary Statements | P261 : Avoid breathing dust. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| EC Number | 253-819-2 |
| RTECS# | NK8226000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2930909899 |
Application
Sulindac: A Nonsteroidal Anti-Inflammatory Drug (NSAID) with Unique Metabolisms
Sulindac is a nonsteroidal anti-inflammatory drug that has anti-inflammatory, analgesic and antipyretic activities. The mechanism of action, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition. Sulindac is a unique prodrug. Slindac is reversibly metabolized to sulindac sulfide [S0906] which has anti-inflammatory and analgesic properties and is irreversibly metabolized to sulindac sulfone which has been suggested to possess antiproliferative effects against tumors. (The product is for research purpose only.)
References
- The disposition of sulindac
- Chemical and biological studies on indomethacin, sulindac and their analogs (a review)
- Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis
- Sulindac and its derivatives: a novel class of anticancer agents (a review)
- NSAID sulindac and its analog bind RXRα and inhibit RXRα-dependent AKT signaling
- Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage
- Sulindac (a review on the synthesis, physical properties, methods of detection, drug metabolism, pharmacokinetics, etc.)
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