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Published TCIMAIL newest issue No.197
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CAS RN: 530-78-9 | Product Number: T2354
2-(3-Trifluoromethylanilino)benzoic Acid
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-[(3-Trifluoromethylphenyl)amino]benzoic Acid
- N-(3-Trifluoromethylphenyl)anthranilic Acid
- Flufenamic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
42,00 €
|
15 | 6 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T2354 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__1__0F__3NO__2 = 281.23 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 530-78-9 |
| Reaxys Registry Number | 1996069 |
| PubChem Substance ID | 87558841 |
| Merck Index (14) | 4132 |
| MDL Number | MFCD00002422 |
Specifications
| Appearance | White to Light yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 133.0 to 137.0 °C |
Properties (reference)
| Melting Point | 135 °C |
| Solubility (soluble in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| EC Number | 208-494-1 |
| RTECS# | CB4375000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2922498590 |
Application
Flufenamic acid: An Ion Channel Modulator
Flufenamic acid has been known as a non-steroidal anti-inflammatory agent since the 1960s which can interfere with prostaglandin synthesis. Recently, flufenamic acid has been reported as an ion channel (e.g. TRPM) modulator. TRPM (transient receptor potential melastatin) is a family of transient receptor potential ion channels which play critical roles in mediating cellular responses to a wide range of physiological stimuli that can induce cell death. (The product is for research purpose only.)
References
- The role of TRPM channels in cell death (a review)
- TRPM2 Cation Channels, Oxidative Stress and Neurological Diseases: Where Are We Now? (a review)
- Flufenamic acid as an ion channel modulator (a review)
- Flufenamic acid (a review on the properties, synthesis, metabolism, pharmacology, and methods of detection)
- Determination of diclofenac sodium, flufenamic acid, indomethacin and ketoprofen by LC-APCI-MS
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