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Published TCIMAIL newest issue No.197
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CAS RN: 32004-67-4 | Product Number: S0906
Sulindac Sulfide
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Purity: >98.0%(HPLC)
Synonyms:
- 5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
115,00 €
|
1 | 5 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | S0906 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__1__7FO__2S = 340.41 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 32004-67-4 |
| Reaxys Registry Number | 2767481 |
| MDL Number | MFCD00869764 |
Specifications
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 184.0 to 188.0 °C |
Properties (reference)
| Melting Point | 186 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. H317 : May cause an allergic skin reaction. |
| Precautionary Statements | P261 : Avoid breathing dust. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. |
Related Laws:
| EC Number | 250-892-2 |
| RTECS# | NK8236000 |
Transport Information:
| HS Number | 2930909899 |
Application
A Cyclooxygenases (COX) Inhibitor, Sulindac Sulfide
Sulindac sulfide, an active metabolite of sulindac sulfoxide (sulindac) [U0099], is a cyclooxygenases (COX) inhibitor. In recent years, there has been growing interest in Sulindac sulfide and other non-steroidal anti-inflammatory drugs (NSAID) because of their anti-tumor activity. Studies with sulindac sulfide have been indicated that it may also function as an anti-tumor agent by stimulating apoptosis. (The product is for research purpose only.)
References
- A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
- Effects of sulindac and oltipraz on the tumorigenicity of 4-(methylnitrosamino)1-(3-pyridyl)-1-butanone in A/J mouse lung
- Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells
- Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis
- Sulindac induces apoptosis and inhibits tumor growth in vivo in head and neck squamous cell carcinoma
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