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CAS RN: 72559-06-9 | Product Number: R0211
Rifabutin
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Purity: >98.0%(HPLC)
Synonyms:
- Ansamycin
- LM-427
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
€79.00
|
Contact Us | 8 |
|
| 1G |
€477.00
|
Contact Us | 3 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | R0211 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__4__6H__6__2N__4O__1__1 = 847.02 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 72559-06-9 |
| Reaxys Registry Number | 3584778 |
| PubChem Substance ID | 468592785 |
| Merck Index (14) | 8213 |
| MDL Number | MFCD00866816 |
Specifications
| Appearance | Red to Dark red to Dark purple powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
Properties (reference)
| Melting Point | 156 °C |
| Maximum Absorption Wavelength | 493 nm (MeOH) |
| Solubility (soluble in) | Methanol |
| Solubility (slightly sol. in) | Ethanol |
GHS
Related Laws:
| RTECS# | VJ6700000 |
Transport Information:
| HS Number | 2941900000 |
Application
Rifabutin: a derivative of rifamycin S with anti-mycobacteria activity
Rifabutin is a derivative of rifamycin S [R0200], belonging to the class of ansamycins, with activity against mycobacteria including atypical organisms such as Mycobacterium avium and M. intracellulare, also referred to as Mycobacterium avium-intracellulare complex (MAC). Rifabutin inhibits DNA-dependent RNA polymerase in susceptible strains of Escherichia coli and Bacillus subtilis but not in mammalian cells. (The product is for research purpose only.)
References
- Rifabutin: a review of its antimicrobial activity, pharmacokinetic properties and therapeutic efficacy
- Rifamycin-Mode of Action, Resistance, and Biosynthesis (a review)
- Update on Rifampin and Rifabutin Drug Interactions
- Determination of twelve antiretroviral agents in human plasma sample using reversed-phase high-performance liquid chromatography
- Identification of rat urinary metabolites of rifabutin using LC-MSn and LC-HR-MS
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