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Published TCIMAIL newest issue No.197
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CAS RN: 73590-58-6 | Product Number: O0359
Omeprazole
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€68.00
|
13 | ≥40 |
|
| 25G |
€236.00
|
1 | 21 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | O0359 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__1__9N__3O__3S = 345.42 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Heat Sensitive |
| CAS RN | 73590-58-6 |
| Reaxys Registry Number | 3628192 |
| PubChem Substance ID | 87560875 |
| Merck Index (14) | 6845 |
| MDL Number | MFCD00083192 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 151 °C(dec.) |
| Solubility in water | Insoluble |
| Solubility (slightly sol. in) | Ethanol, Methanol |
| Solubility (insoluble in) | Ether |
GHS
Related Laws:
| RTECS# | DD9087000 |
Transport Information:
| HS Number | 2933399990 |
Application
Exosome research
Reference
- Effect of Proton Pump Inhibitor Pretreatment on Resistance of Solid Tumors to Cytotoxic Drugs
Application
最初に開発されたプロトンポンプ阻害剤 (PPI)，オメプラゾール
Omeprazole is the first proton pump inhibitor (PPI) that reduces gastric acid secretion. PPIs, such as omeprazole, lansoprazole [L0233], rabeprazole [R0115] and pantoprazole, are metabolized by cytochrome P 450 isoenzymes, 2C19 (CYP2C19) in the liver. The active (S)-enantiomer of omeprazole is esomeprazole. In additon, combinations of omeprazole as a PPI, amoxicillin [A2099], clarithromycin [C2220] and metronidazole [M0924] or another antibiotic have been reported to be effective in the treatment of Helicobacter pylori infection. Omeprazole is synthesized by the oxidation of omeprazole sulfide [O0437].
References
- Omeprazole. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in peptic ulcer disease and Zollinger-Ellison syndrome
- Omeprazole: the first proton pump inhibitor (a review)
- Omeprazole A review of its use in Helicobacter pylori infection, gastro-esophageal reflux disease and peptic ulcers induced by nonsteroidal anti-inflammatory drugs
- A proton-pump inhibitor expedition: the case histories of omeprazole and esomeprazole (a review)
- Pharmacogenomics of proton pump inhibitors (a review)
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Articles/Brochures
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