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Published TCIMAIL newest issue No.197
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CAS RN: 940310-85-0 | Product Number: N1099
NVP-BHG 712
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Purity: >95.0%(HPLC)
Synonyms:
- 4-Methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 10MG |
€115.00
|
1 | Contact Us |
|
| 50MG |
€388.00
|
2 | 15 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | N1099 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__6H__2__0F__3N__7O = 503.49 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 940310-85-0 |
| PubChem Substance ID | 354335680 |
| MDL Number | MFCD20272929 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Elemental analysis(Nitrogen) | 18.5 to 20.5 % |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
Transport Information:
| HS Number | 2933998090 |
Application
NVP-BHG712: A Specific EphB4 Kinase Inhibitor
NVP-BHG712 has been reported as a specific EphB4 kinase inhibitor. EPHB4 is a member of the Eph family of receptor tyrosine kinases which play an important role in embryonic blood vessel development and vascular remodeling. Experimental evidence demonstrated tyrosine kinase EphB4 has been associated with tumor angiogenesis, growth and metastasis, thus making it a valuable and attractive target for drug design for therapeutic applications.
References
- The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis
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