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Published TCIMAIL newest issue No.197
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CAS RN: 13860-38-3 | Product Number: M3387
1-Methylpseudouridine
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Purity: >99.0%(HPLC)
Synonyms:
- 1-Methyl-5-β-D-ribofuranosyluracil
- 1-Methyl-5-β-D-ribofuranosyl-2,4(1H,3H)-pyrimidinedione
- (1S)-1,4-Anhydro-1-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)-D-ribitol
- m1ψ
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
245,00 €
|
1 | 13 |
|
| 1G |
868,00 €
|
2 | 20 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | M3387 |
| Purity / Analysis Method | >99.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__4N__2O__6 = 258.23 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image), 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 13860-38-3 |
| Reaxys Registry Number | 551569 |
| MDL Number | MFCD10687017 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Purity(qNMR) | min. 98.0 % |
| Melting point | 187.0 to 191.0 °C |
| Specific rotation | -6.0 to -8.0 deg (C=1, water) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 189 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2934999090 |
Application
1-Methylpseudouridine (m1Ψ): A Non-Natural Pyrimidine Nucleoside Found in mRNA Vaccines
In recent years, numerous studies have demonstrated the outstanding abilities of mRNA to elicit potent immune, making it a viable new platform for vaccine development1). Additionally there are reports on incorporation of modified nucleobases into mRNA offering advantages for the generation of potent and long-lived antibody responses. In protein biosynthesis, 1-methylpseudouridine (m1Ψ) and pseudouridine (Ψ) [P2939 (synthetic)] [P2396] are read like uridine (U) and enable comparatively high protein yields. Furthermore, m1Ψ enhances immune evasion, protein production, and consequently vaccine efficacy.2-4)
References
- 1) mRNA vaccine for cancer immunotherapy (a review)
- 2) N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice
- 3) N1-methyl-pseudouridine in mRNA enhances translation through eIF2α dependent and independent mechanisms by increasing ribosome density
- 4) Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines (a review)
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