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Published TCIMAIL newest issue No.197
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CAS RN: 33342-05-1 | Product Number: G0332
Gliquidone
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€51.00
|
Contact Us | 1 |
|
| 5G |
€176.00
|
1 | 1 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | G0332 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__7H__3__3N__3O__6S = 527.64 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 33342-05-1 |
| Reaxys Registry Number | 1559726 |
| PubChem Substance ID | 87560715 |
| SDBS (AIST Spectral DB) | 52393 |
| Merck Index (14) | 4443 |
| MDL Number | MFCD00631870 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 177.0 to 188.3 °C |
Properties (reference)
| Melting Point | 179 °C |
GHS
Related Laws:
| EC Number | 251-463-2 |
| RTECS# | DB1584250 |
Transport Information:
| HS Number | 2935909099 |
Application
Gliquidone: A Sulfonylurea ATP-Dependent K+ Channel Antagonist
Gliquidone belongs to sulfonylurea antidiabetics which increase the release of insulin from pancreatic B-cells. Sulfonylurea antidiabetics inhibit ATP-gated K+ channels and thereby cause depolarization of the B-cell membrane. The depolarization leads to activation of voltage-dependent Ca channels and Ca2+ influx into the B-cell, and eventually increases insulin release. (The product is for research purpose only.)
References
- The receptor for antidiabetic sulfonylureas controls the activity of the ATP-modulated K+ channel in insulin-secreting cells
- Glucose, sulfonylureas, and neurotransmitter release: role of ATP-sensitive K+ channels
- Gliquidone, an ATP-dependent K+ channel antagonist, antagonizes morphine-induced hypermotility
- Development of a RP-HPLC method for screening potentially counterfeit anti-diabetic drugs
- Simultaneous determination of gliquidone, pioglitazone hydrochloride, and verapamil in formulation and human serum by RP-HPLC
PubMed Literature
Articles/Brochures
TCIMAIL
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