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Published TCIMAIL newest issue No.197
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CAS RN: 1431-39-6 | Product Number: D5405
Dansylamide [for Albumin binding assay]
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![Dansylamide [for Albumin binding assay]](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "Dansylamide [for Albumin binding assay]")
Purity: >98.0%(T)
Synonyms:
- 5-Dimethylaminonaphthalene-1-sulfonamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
22,00 €
|
1 | Contact Us |
|
| 100MG |
63,00 €
|
1 | 14 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D5405 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__1__2H__1__4N__2O__2S = 250.32 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image), 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 1431-39-6 |
| Reaxys Registry Number | 2217203 |
| PubChem Substance ID | 354335223 |
| SDBS (AIST Spectral DB) | 11148 |
| MDL Number | MFCD00004000 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 218.0 to 222.0 °C |
| Human serum albmin (HSA) binding activity | S/N ratio min. 4 |
| Competitive avtivity in competitive drug | Remaining fluorescein inensity max. 70 % |
| Non-competitive avtivity in non-competitive drug | Remaining fluoresein intensity min. 80 % |
Properties (reference)
| Melting Point | 219 °C |
| Solubility (soluble in) | Dimethylformamide |
GHS
Related Laws:
| EC Number | 215-854-1 |
Transport Information:
| HS Number | 2935909099 |
Application
Fluorescent Probes for the Characterization of Two Specific Drug Binding Sites on HSA
Human Serum Albumin (HSA) binds to a wide variety of drugs at two primary binding sites (I: blue and II: yellow), and can have a significant impact on their pharmacokinetics and pharmacological effects. The fluorescent probes, dansylamide (1) and dansylglycine (2) selectively interact with sites I and II, respectively.1,2) BD140 (3) also binds to drug binding site II specifically.3) Changes in probe fluorescence are analyzed by fluorescence titrations as a result of competitive displacient by drugs and pharmaceuticals. The pattern of fluorescent probe displacient by these reagents enabled the identification of two specific drug binding sites, which illustrates their usefulness for the characterization of the binding sites in HSA.
References
- 1)The Characterization of Two Specific Drug Binding Sites on Human Serum Albumin
- 2)Further Characterization of Specific Drug Binding Sites on Human Serum Albumin
- 3)Fluorescent Dye Cocktail for Multiplex Drug-Site Mapping on Human Serum Albumin
Application
Specific fluorescent probe binding to drug binding site 1 on human serum albumin (HSA)
References
- Drug binding properties of glycosylated human serum albumin as measured by fluorescence and circular dichroism
- A general, wide-rage spectrofluorometric method for measuring the site-specific affinities of drugs toward human serum albumin
- Structural and functional insights into S-thiolation of human serum albumins
- Binding modes of environmental endocrine disruptors to human serum albumin: insights from STD-NMR, ITC, spectroscopic and molecular docking studies
- 8‐Prenylnaringenin tissue distribution and pharmacokinetics in mice and its binding to human serum albumin and cellular uptake in human embryonic kidney cells
PubMed Literature
Articles/Brochures
TCIMAIL
[Product Highlights] Fluorescent Probes for the Characterization of Two Specific Drug Binding Sites on HSA[Product Highlights] Fluorescent Probe for Human Serum Albumin (HSA)-Drug Binding Assay
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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Other Documents
Related Products
![Dansylamide [for Fluorometry]](/medias/D1507.jpg?context=bWFzdGVyfHJvb3R8Mjc3MjN8aW1hZ2UvanBlZ3xhRGd3TDJnNU55ODVNVGN6T1RZNU5EWTVORGN3TDBReE5UQTNMbXB3Wnd8Yzk1MDNmYmNhZjdjMzJjYTEyNmRlYTk5OWNiMjg0M2RmM2Q1MzNhZmQ4NDRlMjczZjRhNTUxODI1MTYwOTcxYg "Dansylamide [for Fluorometry]")
Dansylamide [for Fluorometry]
| Product # | D1507 |
| CAS RN | 1431-39-6 |
| Purity / Analysis Method: | >98.0%(T) |