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Published TCIMAIL newest issue No.197
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CAS RN: 64-86-8 | Product Number: C0380
Colchicine (contains 5% Ethyl Acetate at maximum)
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Purity: >97.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 500MG |
38,00 €
|
5 | ≥100 |
|
| 5G |
238,00 €
|
24 | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C0380 |
| Purity / Analysis Method | >97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__5NO__6 = 399.44 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Hygroscopic |
| Packaging and Container | 500MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 64-86-8 |
| Reaxys Registry Number | 2228813 |
| PubChem Substance ID | 87565511 |
| Merck Index (14) | 2471 |
| MDL Number | MFCD00078484 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 %(calcd.on dried substance) |
| Specific rotation [a]20/D | -230 to -245 deg(C=1, EtOH) |
| Drying loss | max. 5.0 % |
Properties (reference)
| Melting Point | 150 °C |
| Specific Rotation | -238° (C=1,EtOH) |
| Solubility in water | Soluble |
| Solubility (soluble in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. H371 : May cause damage to organs. H340 : May cause genetic defects. |
| Precautionary Statements | P260 : Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| EC Number | 200-598-5 |
| RTECS# | GH0700000 |
Transport Information:
| UN Number | UN1544 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2939799090 |
Application
Colchicine: An Antimitotic Alkaloid
Colchicine is an alkaloid, extracted from plants of the genus Colchicum. Colchicine inhibits β-tubulin polymerization into microtubules by binding to tubulin. Thus, colchicine is an antimitotic agent with a great pharmaceutical potential as an antitumor agent. Colchicine also inhibits neutrophil motility and activity, leading to a net anti-inflammatory effect. (The product is for research purpose only.)
References
- Antitumor Agents. 199.Three-Dimensional Quantitative Structure-Activity Relationship Study of the Colchicine Binding Site Ligands Using Comparative Molecular Field Analysis
- Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain
- Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin (a review)
- An Overview of Tubulin Inhibitors That Interact with the Colchicine Binding Site (a review)
- Colchicine today (a review)
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